TRI64_HUMAN
ID TRI64_HUMAN Reviewed; 449 AA.
AC A6NGJ6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 4.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Tripartite motif-containing protein 64;
GN Name=TRIM64; Synonyms=C11orf28;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 249-449.
RA Ebert L., Heil O., Hennig S., Neubert P., Partsch E., Peters M.,
RA Radelof U., Schneider D., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR EMBL; AP004607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX093574; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS73363.1; -.
DR RefSeq; NP_001129958.1; NM_001136486.1.
DR RefSeq; XP_011540887.1; XM_011542585.2.
DR AlphaFoldDB; A6NGJ6; -.
DR SMR; A6NGJ6; -.
DR STRING; 9606.ENSP00000483764; -.
DR iPTMnet; A6NGJ6; -.
DR PhosphoSitePlus; A6NGJ6; -.
DR BioMuta; TRIM64; -.
DR PeptideAtlas; A6NGJ6; -.
DR PRIDE; A6NGJ6; -.
DR Antibodypedia; 72942; 66 antibodies from 14 providers.
DR DNASU; 120146; -.
DR Ensembl; ENST00000533122.3; ENSP00000483764.1; ENSG00000204450.8.
DR GeneID; 120146; -.
DR KEGG; hsa:120146; -.
DR MANE-Select; ENST00000533122.4; ENSP00000483764.1; NM_001136486.2; NP_001129958.1.
DR UCSC; uc010rty.3; human.
DR CTD; 120146; -.
DR GeneCards; TRIM64; -.
DR HGNC; HGNC:14663; TRIM64.
DR HPA; ENSG00000204450; Tissue enriched (placenta).
DR neXtProt; NX_A6NGJ6; -.
DR PharmGKB; PA25492; -.
DR VEuPathDB; HostDB:ENSG00000204450; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163440; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; A6NGJ6; -.
DR OMA; NNSHRIC; -.
DR OrthoDB; 704031at2759; -.
DR PhylomeDB; A6NGJ6; -.
DR PathwayCommons; A6NGJ6; -.
DR BioGRID-ORCS; 120146; 13 hits in 185 CRISPR screens.
DR GenomeRNAi; 120146; -.
DR Pharos; A6NGJ6; Tdark.
DR PRO; PR:A6NGJ6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A6NGJ6; protein.
DR Bgee; ENSG00000204450; Expressed in placenta and 2 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..449
FT /note="Tripartite motif-containing protein 64"
FT /id="PRO_0000331574"
FT DOMAIN 269..449
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 15..56
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 87..128
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT COILED 189..225
FT /evidence="ECO:0000255"
FT BINDING 92
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 95
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 114
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 120
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 449 AA; 51566 MW; 57B53A10C6E00C61 CRC64;
MDSDDLQVFQ NELICCICVN YFIDPVTIDC GHSFCRPCLC LCSEEGRAPM RCPSCRKISE
KPNFNTNVVL KKLSSLARQT RPQNINSSDN ICVLHEETKE LFCEADKRLL CGPCSESPEH
MAHSHSPIGW AAEECREKLI KEMDYLWEIN QETRNNLNQE TRTFHSLKDY VSVRKRIITI
QYQKMPIFLD EEEQRHLQAL EREAEELFQQ LQDSQVRMTQ HLERMKDMYR ELWETCHVPD
VELLQDVRNV SARTDLAQMQ KPQPVNPELT SWCITGVLDM LNNFRVDSAL STEMIPCYIS
LSEDVRYVIF GDDHLSAPTD PQGVDSFAVW GAQAFTSGKH YWEVDVTLSS NWILGVCQDS
RTADANFVID SDERFFLISS KRSNHYSLST NSPPLIQYVQ RPLGQVGVFL DYDNGSVSFF
DVSKGSLIYG FPPSSFSSPL RPFFCFGCT
