TRI67_MOUSE
ID TRI67_MOUSE Reviewed; 768 AA.
AC Q505D9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Tripartite motif-containing protein 67;
GN Name=Trim67;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC {ECO:0000250}. Note=Microtubule-associated. {ECO:0000250}.
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DR EMBL; BC094596; AAH94596.1; -; mRNA.
DR CCDS; CCDS52704.1; -.
DR RefSeq; NP_941034.2; NM_198632.2.
DR AlphaFoldDB; Q505D9; -.
DR BioGRID; 237039; 7.
DR IntAct; Q505D9; 1.
DR STRING; 10090.ENSMUSP00000040601; -.
DR iPTMnet; Q505D9; -.
DR PhosphoSitePlus; Q505D9; -.
DR MaxQB; Q505D9; -.
DR PaxDb; Q505D9; -.
DR PeptideAtlas; Q505D9; -.
DR PRIDE; Q505D9; -.
DR ProteomicsDB; 259330; -.
DR Antibodypedia; 34683; 38 antibodies from 16 providers.
DR Ensembl; ENSMUST00000041106; ENSMUSP00000040601; ENSMUSG00000036913.
DR Ensembl; ENSMUST00000167588; ENSMUSP00000130343; ENSMUSG00000036913.
DR Ensembl; ENSMUST00000211867; ENSMUSP00000148625; ENSMUSG00000036913.
DR GeneID; 330863; -.
DR KEGG; mmu:330863; -.
DR UCSC; uc012gmz.1; mouse.
DR CTD; 440730; -.
DR MGI; MGI:3045323; Trim67.
DR VEuPathDB; HostDB:ENSMUSG00000036913; -.
DR eggNOG; KOG4367; Eukaryota.
DR GeneTree; ENSGT00940000154071; -.
DR HOGENOM; CLU_013137_19_2_1; -.
DR InParanoid; Q505D9; -.
DR OMA; IVHRYQQ; -.
DR OrthoDB; 516512at2759; -.
DR PhylomeDB; Q505D9; -.
DR TreeFam; TF315216; -.
DR BioGRID-ORCS; 330863; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Trim67; mouse.
DR PRO; PR:Q505D9; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q505D9; protein.
DR Bgee; ENSMUSG00000036913; Expressed in cortical plate and 71 other tissues.
DR Genevisible; Q505D9; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:MGI.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IDA:MGI.
DR GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IDA:MGI.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR017903; COS_domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 2.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51262; COS; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Metal-binding; Reference proteome;
KW Repeat; Zinc; Zinc-finger.
FT CHAIN 1..768
FT /note="Tripartite motif-containing protein 67"
FT /id="PRO_0000256865"
FT DOMAIN 435..493
FT /note="COS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00586"
FT DOMAIN 498..592
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 574..765
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 7..42
FT /note="RING-type; degenerate"
FT ZN_FING 201..248
FT /note="B box-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT ZN_FING 285..327
FT /note="B box-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT REGION 55..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 332..369
FT /evidence="ECO:0000255"
FT BINDING 290
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 293
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 313
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 319
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 768 AA; 82760 MW; 5C59C4A62A79C436 CRC64;
MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GEQHLPPPLL LSRGAAAAAT
PPDQDAAAGA TSGGAGANTA GGLGGGATGG GDHADKLSLY SETDSGYGSY TPSLKSPNGV
RVLPMVPAPP GSSAAAARGA ACSSLCSSSS SITCPQCHRS ASLDHRGLRG FQRNRLLEGI
VQRYQQGRGV VPGAAAAPAV AICQLCDRTP PEPAATLCEQ CDVLYCATCQ LKCHPSRGPF
AKHRLVQPPP PPTPPEATPA VTGTSTASSA GGCRSPGGAG ASAPRKFPTC PEHEMENYSM
YCVSCRSPVC YMCLEEGRHS KHEVKPLGAT WKQHKAQLSQ ALNGVSDKAK EAKEFLVQLK
NILQQIQENG LDYEACLVAQ CDALVDALTR QKAKLLTKVT KEREHKLKMV WDQINHCTLK
LRQSTGLMEY CLEVIKEDDP SGFLQISDAL IKRVQTSQEQ WVKGALEPKV SAEFDLTLDS
EPLLQAIHQL DFVQMKLPPV PLLQLEKCCT RNNSVTLAWR TPPFTHSPAE GYILELDDGD
GGQFREVYVG KETLCTIDGL HFNSTYNARV KAFNSSGVGP YSKTVVLQTS DVAWFTFDPN
SGHRDIILSN DNQTATCSSY DDRVVLGTAA FSKGVHYWEL HVDRYDNHPD PAFGVARASV
VKDMMLGKDD KAWAMYVDNN RSWFMHCNSH TNRTEGGVCK GATVGVLLDL NKHTLTFFIN
GQQQGPTAFS HVDGVFMPAL SLNRNVQVTL HTGLEVPTNL GRPKLSGN
