ID   TRI6_FUSSP              Reviewed;         217 AA.
AC   Q00856;
DT   22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Trichothecene biosynthesis transcription regulator TRI6 {ECO:0000303|PubMed:7646028};
DE   AltName: Full=Core trichothecene cluster (CTC) protein 6 {ECO:0000303|PubMed:11352533};
GN   Name=TRI6 {ECO:0000303|PubMed:7646028};
OS   Fusarium sporotrichioides.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=5514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 24631 / NRRL 3299;
RX   PubMed=7646028; DOI=10.1128/aem.61.5.1923-1930.1995;
RA   Proctor R.H., Hohn T.M., McCormick S.P., Desjardins A.E.;
RT   "Tri6 encodes an unusual zinc finger protein involved in regulation of
RT   trichothecene biosynthesis in Fusarium sporotrichioides.";
RL   Appl. Environ. Microbiol. 61:1923-1930(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 24631 / NRRL 3299;
RX   PubMed=11352533; DOI=10.1006/fgbi.2001.1256;
RA   Brown D.W., McCormick S.P., Alexander N.J., Proctor R.H., Desjardins A.E.;
RT   "A genetic and biochemical approach to study trichothecene diversity in
RT   Fusarium sporotrichioides and Fusarium graminearum.";
RL   Fungal Genet. Biol. 32:121-133(2001).
RN   [3]
RP   FUNCTION.
RX   PubMed=16347944; DOI=10.1128/aem.55.6.1500-1503.1989;
RA   Hohn T.M., Beremand M.N.;
RT   "Regulation of trichodiene synthase in Fusarium sporotrichioides and
RT   Gibberella pulicaris (Fusarium sambucinum).";
RL   Appl. Environ. Microbiol. 55:1500-1503(1989).
RN   [4]
RP   FUNCTION.
RC   STRAIN=ATCC 24631 / NRRL 3299;
RX   PubMed=12732543; DOI=10.1128/aem.69.5.2731-2736.2003;
RA   Peplow A.W., Tag A.G., Garifullina G.F., Beremand M.N.;
RT   "Identification of new genes positively regulated by Tri10 and a regulatory
RT   network for trichothecene mycotoxin production.";
RL   Appl. Environ. Microbiol. 69:2731-2736(2003).
CC   -!- FUNCTION: Transcriptional activator of part of the core trichothecene
CC       biosynthesis cluster (PubMed:7646028, PubMed:11352533, PubMed:16347944,
CC       PubMed:12732543). {ECO:0000269|PubMed:12732543,
CC       ECO:0000269|PubMed:16347944, ECO:0000269|PubMed:7646028,
CC       ECO:0000305|PubMed:11352533}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Reduces transcription of TRI4 and TRI5 and does
CC       not produce trichothecenes but accumulates low levels of the
CC       trichothecene precursor trichodiene (PubMed:7646028).
CC       {ECO:0000269|PubMed:7646028}.
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DR   EMBL; U22150; AAD11963.1; -; Genomic_DNA.
DR   EMBL; AF359360; AAK33075.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q00856; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR016766; Tscrpt_reg_Tri6.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PIRSF; PIRSF019847; Trans_reg_Tri6; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
PE   4: Predicted;
KW   Metal-binding; Nucleus; Zinc; Zinc-finger.
FT   CHAIN           1..217
FT                   /note="Trichothecene biosynthesis transcription regulator
FT                   TRI6"
FT                   /id="PRO_0000442369"
FT   ZN_FING         185..215
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   217 AA;  25345 MW;  59F423E1995EDCAA CRC64;
     MIYMASGTHY ESWSALPLFD RVASPDHAKD FVPDLNDYES PTFEVDLLSE NYDYDNFLTY
     SLPTVDPTKT LLHEEPLCFE GDFTNPAIDH YITTSSGLLD AVPSQLIALP SFTQPSKCPF
     PNCKSTTIFE SGRDFRRHYR QHFKRFFCRY PDCSQSTQDI MEVGTKGFAT RKDRARHESK
     HKPTVRCPWH DQEGQQCLRV FSRVDNMRDH YRRIHKC