TRI77_HUMAN
ID TRI77_HUMAN Reviewed; 450 AA.
AC I1YAP6;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2013, sequence version 2.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Tripartite motif-containing protein 77;
GN Name=TRIM77; Synonyms=TRIM77P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 152-296.
RX PubMed=22144910; DOI=10.1371/journal.pgen.1002388;
RA Han K., Lou D.I., Sawyer S.L.;
RT "Identification of a genomic reservoir for new TRIM genes in primate
RT genomes.";
RL PLoS Genet. 7:E1002388-E1002388(2011).
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR EMBL; AP003122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JF968445; AFI99088.1; -; mRNA.
DR CCDS; CCDS60929.1; -.
DR RefSeq; NP_001139634.1; NM_001146162.1.
DR AlphaFoldDB; I1YAP6; -.
DR SMR; I1YAP6; -.
DR BioGRID; 133459; 1.
DR IntAct; I1YAP6; 1.
DR STRING; 9606.ENSP00000474003; -.
DR iPTMnet; I1YAP6; -.
DR PhosphoSitePlus; I1YAP6; -.
DR BioMuta; TRIM77; -.
DR PRIDE; I1YAP6; -.
DR Antibodypedia; 72083; 4 antibodies from 4 providers.
DR DNASU; 390231; -.
DR Ensembl; ENST00000398290.7; ENSP00000474003.1; ENSG00000214414.9.
DR GeneID; 390231; -.
DR KEGG; hsa:390231; -.
DR MANE-Select; ENST00000398290.7; ENSP00000474003.1; NM_001146162.1; NP_001139634.1.
DR UCSC; uc010rtw.2; human.
DR CTD; 390231; -.
DR DisGeNET; 390231; -.
DR GeneCards; TRIM77; -.
DR HGNC; HGNC:34228; TRIM77.
DR HPA; ENSG00000214414; Not detected.
DR neXtProt; NX_I1YAP6; -.
DR OpenTargets; ENSG00000214414; -.
DR VEuPathDB; HostDB:ENSG00000214414; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163778; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; I1YAP6; -.
DR OMA; AWTITGM; -.
DR OrthoDB; 565446at2759; -.
DR PhylomeDB; I1YAP6; -.
DR PathwayCommons; I1YAP6; -.
DR SignaLink; I1YAP6; -.
DR BioGRID-ORCS; 390231; 10 hits in 994 CRISPR screens.
DR GenomeRNAi; 390231; -.
DR Pharos; I1YAP6; Tdark.
DR PRO; PR:I1YAP6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; I1YAP6; protein.
DR Bgee; ENSG00000214414; Expressed in putamen.
DR ExpressionAtlas; I1YAP6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..450
FT /note="Tripartite motif-containing protein 77"
FT /id="PRO_0000421830"
FT DOMAIN 269..450
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 15..56
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 88..131
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 96
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 450 AA; 52450 MW; B0DB3E490B6F3F9B CRC64;
MASAITQCST SELTCSICTD YLTDPVTICC GHRFCSPCLC LLWEDTLTPN CCPVCREISQ
QMYFKRIIFA EKQVIPTRES VPCQLSSSAM LICRRHQEIK NLICETDRSL LCFLCSQSPR
HATHKHYMTR EADEYYRKKL LIQMKSIWKK KQKNQRNLNR ETNIIGTWEV FINLRSMMIS
AEYPKVCQYL REEEQKHVES LAREGRIIFQ QLKRSQTRMA KMGILLREMY EKLKEMSCKA
DVNLPQDLGD VMKRNEFLRL AMPQPVNPQL SAWTITGVSE RLNFFRVYIT LDRKICSNHK
LLFEDLRHLQ CSLDDTDMSC NPTSTQYTSS WGAQILSSGK HYWEVDVKDS CNWVIGLCRE
AWTKRNDMRL DSEGIFLLLC LKVDDHFSLF STSPLLPHYI PRPQGWLGVF LDYECGIVSF
VNVAQSSLIC SFLSRIFYFP LRPFICHGSK
