TRIA1_XENTR
ID TRIA1_XENTR Reviewed; 78 AA.
AC A9ULB4;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=TP53-regulated inhibitor of apoptosis 1 {ECO:0000312|EMBL:AAI57193.1};
DE AltName: Full=p53-inducible cell-survival factor {ECO:0000303|PubMed:18472403};
DE Short=p53csv {ECO:0000303|PubMed:18472403};
GN Name=triap1 {ECO:0000312|EMBL:AAI57193.1,
GN ECO:0000312|Xenbase:XB-GENE-949263};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:AAI57193.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:AAI57193.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=18472403; DOI=10.1016/j.mod.2008.03.001;
RA Kyuno J., Masse K., Jones E.A.;
RT "A functional screen for genes involved in Xenopus pronephros
RT development.";
RL Mech. Dev. 125:571-586(2008).
CC -!- FUNCTION: Involved in the modulation of the mitochondrial apoptotic
CC pathway by ensuring the accumulation of cardiolipin (CL) in
CC mitochondrial membranes. The triap1:prelid1 complex probably functions
CC as a phosphatidic acid (PA) transporter across the mitochondrion
CC intermembrane space to provide PA for cardiolipin CL synthesis in the
CC inner membrane. Likewise, the triap1:prelid3a complex mediates the
CC transfer of phosphatidic acid (PA) between liposomes (in vitro) and
CC probably functions as a PA transporter across the mitochondrion
CC intermembrane space (in vivo). Mediates cell survival by inhibiting
CC activation of caspase-9 which prevents induction of apoptosis (By
CC similarity). Required for pronephros development; probably involved at
CC an early stage in the formation of pronephric components derived from
CC the somatic layer (PubMed:18472403). {ECO:0000250|UniProtKB:O43715,
CC ECO:0000269|PubMed:18472403}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-
CC glycero-3-phosphate(out); Xref=Rhea:RHEA:36435, ChEBI:CHEBI:58608;
CC Evidence={ECO:0000250|UniProtKB:O43715};
CC -!- SUBUNIT: Monomer. Forms a complex with prelid1 in the mitochondrion
CC intermembrane space. Interacts with prelid3a.
CC {ECO:0000250|UniProtKB:O43715}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O43715}.
CC Mitochondrion intermembrane space {ECO:0000250|UniProtKB:O43715}.
CC -!- TISSUE SPECIFICITY: Expressed in the developing pronephros.
CC {ECO:0000269|PubMed:18472403}.
CC -!- SIMILARITY: Belongs to the TRIAP1/MDM35 family. {ECO:0000255}.
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DR EMBL; BC157192; AAI57193.1; -; mRNA.
DR RefSeq; NP_001016268.1; NM_001016268.2.
DR AlphaFoldDB; A9ULB4; -.
DR SMR; A9ULB4; -.
DR STRING; 8364.ENSXETP00000026710; -.
DR PaxDb; A9ULB4; -.
DR Ensembl; ENSXETT00000026710; ENSXETP00000026710; ENSXETG00000012223.
DR GeneID; 549022; -.
DR KEGG; xtr:549022; -.
DR CTD; 51499; -.
DR Xenbase; XB-GENE-949263; triap1.
DR eggNOG; KOG3481; Eukaryota.
DR HOGENOM; CLU_101473_4_0_1; -.
DR InParanoid; A9ULB4; -.
DR OMA; CAPIFRI; -.
DR OrthoDB; 1552088at2759; -.
DR PhylomeDB; A9ULB4; -.
DR TreeFam; TF326640; -.
DR Reactome; R-XTR-6803204; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000012223; Expressed in heart and 20 other tissues.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:1902166; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; ISS:UniProtKB.
DR GO; GO:0045332; P:phospholipid translocation; IBA:GO_Central.
DR GO; GO:0015914; P:phospholipid transport; ISS:UniProtKB.
DR GO; GO:0048793; P:pronephros development; IMP:UniProtKB.
DR InterPro; IPR007918; MDM35_apoptosis.
DR PANTHER; PTHR46403; PTHR46403; 1.
DR Pfam; PF05254; UPF0203; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Coiled coil; Developmental protein; Disulfide bond;
KW Lipid transport; Mitochondrion; Reference proteome; Transport.
FT CHAIN 1..78
FT /note="TP53-regulated inhibitor of apoptosis 1"
FT /id="PRO_0000397919"
FT DOMAIN 5..55
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT COILED 1..52
FT /evidence="ECO:0000250|UniProtKB:O43715"
FT MOTIF 8..18
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 37..47
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT SITE 27
FT /note="Important for interaction with prelid3a"
FT /evidence="ECO:0000250|UniProtKB:O43715"
FT SITE 41
FT /note="Important for interaction with prelid3a"
FT /evidence="ECO:0000250|UniProtKB:O43715"
FT DISULFID 8..47
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 18..37
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
SQ SEQUENCE 78 AA; 8944 MW; 4D9BF6C2ADA1EFEF CRC64;
MNSVGEECTD MKREYDQCFN RWFAEKFLKG ECSGDPCTEL FRRYRDCVQK AIKDKDIPVD
GVDFMGPSKS KTESDGSS
