ID   TRIN1_MESSA             Reviewed;          18 AA.
AC   P84712;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   23-FEB-2022, entry version 18.
DE   RecName: Full=Trypsin inhibitor HSTI;
DE   Flags: Fragment;
OS   Mesosphaerum suaveolens (Pignut) (Hyptis suaveolens).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Hyptidinae;
OC   Mesosphaerum.
OX   NCBI_TaxID=204129;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Seed {ECO:0000269|PubMed:15142539};
RX   PubMed=15142539; DOI=10.1016/j.cbpc.2004.02.011;
RA   Aguirre C., Valdes-Rodriguez S., Mendoza-Hernandez G., Rojo-Dominguez A.,
RA   Blanco-Labra A.;
RT   "A novel 8.7 kDa protease inhibitor from chan seeds (Hyptis suaveolens L.)
RT   inhibits proteases from the larger grain borer Prostephanus truncatus
RT   (Coleoptera: Bostrichidae).";
RL   Comp. Biochem. Physiol. 138B:81-89(2004).
CC   -!- FUNCTION: Inhibitor of serine proteases. Can inhibit trypsin but is
CC       ineffective against chymotrypsin, papain and elastase. Strongly
CC       inhibits the trypsin-like protease activity isolated from the third
CC       instar larva of P.truncatus, and also inhibits more weakly the trypsin-
CC       like protease activity isolated from the third instar larva of M.sexta.
CC       Protects the plant by inhibiting proteases of invading organisms.
CC       {ECO:0000269|PubMed:15142539}.
CC   -!- TISSUE SPECIFICITY: Detected in seeds (at protein level).
CC       {ECO:0000269|PubMed:15142539}.
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DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IDA:UniProtKB.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Protease inhibitor; Serine protease inhibitor.
FT   CHAIN           1..>18
FT                   /note="Trypsin inhibitor HSTI"
FT                   /id="PRO_0000065630"
FT   NON_TER         18
FT                   /evidence="ECO:0000303|PubMed:15142539"
SQ   SEQUENCE   18 AA;  2217 MW;  B02EA918AE0993DC CRC64;
     RGWGSDEKKD REEEXEQQ