BUK_BACTN
ID BUK_BACTN Reviewed; 353 AA.
AC Q8A4P5;
DT 15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Probable butyrate kinase {ECO:0000255|HAMAP-Rule:MF_00542};
DE Short=BK {ECO:0000255|HAMAP-Rule:MF_00542};
DE EC=2.7.2.7 {ECO:0000255|HAMAP-Rule:MF_00542};
DE AltName: Full=Branched-chain carboxylic acid kinase {ECO:0000255|HAMAP-Rule:MF_00542};
GN Name=buk {ECO:0000255|HAMAP-Rule:MF_00542}; OrderedLocusNames=BT_2552;
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50;
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + butanoate = ADP + butanoyl phosphate;
CC Xref=Rhea:RHEA:13585, ChEBI:CHEBI:17968, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:58079, ChEBI:CHEBI:456216; EC=2.7.2.7;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00542};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00542}.
CC -!- SIMILARITY: Belongs to the acetokinase family. {ECO:0000255|HAMAP-
CC Rule:MF_00542}.
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DR EMBL; AE015928; AAO77659.1; -; Genomic_DNA.
DR RefSeq; NP_811465.1; NC_004663.1.
DR RefSeq; WP_008765189.1; NC_004663.1.
DR AlphaFoldDB; Q8A4P5; -.
DR SMR; Q8A4P5; -.
DR STRING; 226186.BT_2552; -.
DR PaxDb; Q8A4P5; -.
DR PRIDE; Q8A4P5; -.
DR EnsemblBacteria; AAO77659; AAO77659; BT_2552.
DR GeneID; 60923724; -.
DR KEGG; bth:BT_2552; -.
DR PATRIC; fig|226186.12.peg.2603; -.
DR eggNOG; COG3426; Bacteria.
DR HOGENOM; CLU_048716_0_0_10; -.
DR InParanoid; Q8A4P5; -.
DR OMA; IWHALNQ; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008776; F:acetate kinase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0047761; F:butyrate kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006083; P:acetate metabolic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00542; Butyrate_kinase; 1.
DR InterPro; IPR000890; Aliphatic_acid_kin_short-chain.
DR InterPro; IPR023865; Aliphatic_acid_kinase_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR011245; Butyrate_kin.
DR PANTHER; PTHR21060; PTHR21060; 1.
DR PANTHER; PTHR21060:SF3; PTHR21060:SF3; 1.
DR Pfam; PF00871; Acetate_kinase; 1.
DR PIRSF; PIRSF036458; Butyrate_kin; 1.
DR PRINTS; PR00471; ACETATEKNASE.
DR SUPFAM; SSF53067; SSF53067; 2.
DR TIGRFAMs; TIGR02707; butyr_kinase; 1.
DR PROSITE; PS01075; ACETATE_KINASE_1; 1.
DR PROSITE; PS01076; ACETATE_KINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome;
KW Transferase.
FT CHAIN 1..353
FT /note="Probable butyrate kinase"
FT /id="PRO_0000107667"
SQ SEQUENCE 353 AA; 37855 MW; 0052FB92758FCCDE CRC64;
MKILVINPGS TSTKIAVYEN ETPLLVRNIK HTVEELSVYP QVIDQFEFRK NLVLQELEAN
GIPFAFDAVI GRGGLVKPIP GGVYAVNEAM KQDTLHAMRT HACNLGGLIA AELAASLPDC
PAFIADPGVV DELEDVARIS GSPLMPKITI WHALNQKAIA RRFAKEQGTK YEELDLIICH
LGGGISIAVH QHGKAIDANN ALDGEGPFSP ERAGTLPAGQ LIDICYSGQF TKDELKKRIS
GRAGLTAHLG TTDVPAIIKA IEEGDKKAEL ILDAMIYNVA KAIGGAATVL CGKVDAILLT
GGIAYSDYII SRLKKRISFL APIHVYPGEG EMESLAFNAL GALRGELPVQ IYK
