TRIQK_HUMAN
ID TRIQK_HUMAN Reviewed; 86 AA.
AC Q629K1;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Triple QxxK/R motif-containing protein;
DE AltName: Full=Triple repetitive-sequence of QXXK/R protein homolog;
GN Name=TRIQK; Synonyms=C8orf83;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RX PubMed=18828657; DOI=10.2108/zsj.25.706;
RA Onuma Y., Watanabe A., Aburatani H., Asashima M., Whitman M.;
RT "TRIQK, a novel family of small proteins localized to the endoplasmic
RT reticulum membrane, is conserved across vertebrates.";
RL Zool. Sci. 25:706-713(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Onuma Y., Whitman M.;
RT "Characterization of endoplasmic reticulum localized mitosis interference
RT factor (ERMIN).";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in cell growth and maintenance of cell
CC morphology. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:18828657}; Single-pass membrane protein
CC {ECO:0000269|PubMed:18828657}.
CC -!- SIMILARITY: Belongs to the TRIQK family. {ECO:0000305}.
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DR EMBL; DQ351291; ABC84190.1; -; mRNA.
DR EMBL; CR749421; CAH56121.1; -; mRNA.
DR EMBL; CH471060; EAW91691.1; -; Genomic_DNA.
DR CCDS; CCDS55261.1; -.
DR RefSeq; NP_001165266.1; NM_001171795.1.
DR RefSeq; NP_001165267.1; NM_001171796.1.
DR RefSeq; NP_001165268.1; NM_001171797.1.
DR RefSeq; NP_001165269.1; NM_001171798.1.
DR RefSeq; NP_001165270.1; NM_001171799.1.
DR RefSeq; NP_001177964.1; NM_001191035.1.
DR RefSeq; NP_001177965.1; NM_001191036.1.
DR RefSeq; XP_016868836.1; XM_017013347.1.
DR RefSeq; XP_016868837.1; XM_017013348.1.
DR RefSeq; XP_016868838.1; XM_017013349.1.
DR RefSeq; XP_016868839.1; XM_017013350.1.
DR AlphaFoldDB; Q629K1; -.
DR SMR; Q629K1; -.
DR BioGRID; 130312; 1.
DR STRING; 9606.ENSP00000429517; -.
DR iPTMnet; Q629K1; -.
DR PhosphoSitePlus; Q629K1; -.
DR BioMuta; TRIQK; -.
DR DMDM; 74708352; -.
DR EPD; Q629K1; -.
DR jPOST; Q629K1; -.
DR MassIVE; Q629K1; -.
DR PaxDb; Q629K1; -.
DR PeptideAtlas; Q629K1; -.
DR PRIDE; Q629K1; -.
DR ProteomicsDB; 65875; -.
DR TopDownProteomics; Q629K1; -.
DR Antibodypedia; 77803; 2 antibodies from 2 providers.
DR DNASU; 286144; -.
DR Ensembl; ENST00000378861.9; ENSP00000368138.5; ENSG00000205133.12.
DR Ensembl; ENST00000518748.5; ENSP00000430837.1; ENSG00000205133.12.
DR Ensembl; ENST00000519969.5; ENSP00000429381.1; ENSG00000205133.12.
DR Ensembl; ENST00000520430.5; ENSP00000428822.1; ENSG00000205133.12.
DR Ensembl; ENST00000520686.5; ENSP00000429822.1; ENSG00000205133.12.
DR Ensembl; ENST00000521617.5; ENSP00000430992.1; ENSG00000205133.12.
DR Ensembl; ENST00000521988.6; ENSP00000429517.1; ENSG00000205133.12.
DR Ensembl; ENST00000524107.5; ENSP00000429742.1; ENSG00000205133.12.
DR Ensembl; ENST00000537541.1; ENSP00000442030.1; ENSG00000205133.12.
DR GeneID; 286144; -.
DR KEGG; hsa:286144; -.
DR MANE-Select; ENST00000521988.6; ENSP00000429517.1; NM_001171797.2; NP_001165268.1.
DR UCSC; uc003yfk.5; human.
DR CTD; 286144; -.
DR DisGeNET; 286144; -.
DR GeneCards; TRIQK; -.
DR HGNC; HGNC:27828; TRIQK.
DR HPA; ENSG00000205133; Low tissue specificity.
DR neXtProt; NX_Q629K1; -.
DR OpenTargets; ENSG00000205133; -.
DR PharmGKB; PA164717477; -.
DR VEuPathDB; HostDB:ENSG00000205133; -.
DR eggNOG; ENOG502S3QR; Eukaryota.
DR GeneTree; ENSGT00390000017350; -.
DR InParanoid; Q629K1; -.
DR OMA; NIGKQDY; -.
DR OrthoDB; 1639030at2759; -.
DR PhylomeDB; Q629K1; -.
DR TreeFam; TF328583; -.
DR PathwayCommons; Q629K1; -.
DR SignaLink; Q629K1; -.
DR BioGRID-ORCS; 286144; 15 hits in 1011 CRISPR screens.
DR ChiTaRS; TRIQK; human.
DR GenomeRNAi; 286144; -.
DR Pharos; Q629K1; Tdark.
DR PRO; PR:Q629K1; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q629K1; protein.
DR Bgee; ENSG00000205133; Expressed in epithelial cell of pancreas and 187 other tissues.
DR ExpressionAtlas; Q629K1; baseline and differential.
DR Genevisible; Q629K1; HS.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR024842; TRIQK.
DR PANTHER; PTHR20583; PTHR20583; 1.
DR Pfam; PF15168; TRIQK; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..86
FT /note="Triple QxxK/R motif-containing protein"
FT /id="PRO_0000340674"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 86 AA; 9683 MW; 34406C99BDDCD531 CRC64;
MGRKDAATIK LPVDQYRKQI GKQDYKKTKP ILRATKLKAE AKKTAIGIKE VGLVLAAILA
LLLAFYAFFY LRLTTDVDPD LDQDED
