ID   TRIQK_XENLA             Reviewed;          84 AA.
AC   B2B9D9;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Triple QxxK/R motif-containing protein;
DE   AltName: Full=Triple repetitive-sequence of QXXK/R protein;
GN   Name=triqk;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL
RP   STAGE, AND TISSUE SPECIFICITY.
RC   TISSUE=Egg;
RX   PubMed=18828657; DOI=10.2108/zsj.25.706;
RA   Onuma Y., Watanabe A., Aburatani H., Asashima M., Whitman M.;
RT   "TRIQK, a novel family of small proteins localized to the endoplasmic
RT   reticulum membrane, is conserved across vertebrates.";
RL   Zool. Sci. 25:706-713(2008).
CC   -!- FUNCTION: Plays a role in cell growth and maintenance of cell
CC       morphology. {ECO:0000269|PubMed:18828657}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:18828657}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:18828657}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from oocyte to tadpole stages. Expressed
CC       in all animal, marginal and vegetal parts of blastula embryos.
CC       Expressed broadly in the head, trunk and tail region of tadpoles.
CC       Expressed in the midline at the neurula stage; the signal is detected
CC       in the notochord, neuroal tube and cement gland.
CC       {ECO:0000269|PubMed:18828657}.
CC   -!- DOMAIN: Both the conserved triple repeat of the QXXK/R motif and the
CC       hydrophobic region are essential for its activity. The hydrophobic
CC       region contributes to the endoplasmic reticulum membrane localization.
CC   -!- SIMILARITY: Belongs to the TRIQK family. {ECO:0000305}.
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DR   EMBL; DQ351290; ABC84189.1; -; mRNA.
DR   RefSeq; NP_001121324.1; NM_001127852.1.
DR   AlphaFoldDB; B2B9D9; -.
DR   SMR; B2B9D9; -.
DR   GeneID; 100158412; -.
DR   KEGG; xla:100158412; -.
DR   CTD; 100158412; -.
DR   Xenbase; XB-GENE-6252747; triqk.L.
DR   OMA; NIGKQDY; -.
DR   OrthoDB; 1639030at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 100158412; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR024842; TRIQK.
DR   PANTHER; PTHR20583; PTHR20583; 1.
DR   Pfam; PF15168; TRIQK; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..84
FT                   /note="Triple QxxK/R motif-containing protein"
FT                   /id="PRO_0000398148"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   84 AA;  9584 MW;  715CD0E6C23730A9 CRC64;
     MGKKDASTTR TPVDQYRKQI GRQDYKKNKP VLKATRLKAE AKKAAIGIKE VILVTIAILV
     LLFAFYAFFF LNLTKTDIYE DSNN