TRIR_MOUSE
ID TRIR_MOUSE Reviewed; 173 AA.
AC Q9D735; Q9D1N3;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Telomerase RNA component interacting RNase {ECO:0000312|MGI:MGI:1922833};
DE EC=3.1.13.- {ECO:0000250|UniProtKB:Q9BQ61};
DE AltName: Full=Exoribonuclease Trir {ECO:0000305};
GN Name=Trir {ECO:0000312|MGI:MGI:1922833};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-143, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- FUNCTION: Exoribonuclease that is part of the telomerase RNA 3' end
CC processing complex and which has the ability to all four unpaired RNA
CC nucleotides from 5' end or 3' end with higher efficiency for purine
CC bases (By similarity). {ECO:0000250|UniProtKB:Q9BQ61}.
CC -!- SUBUNIT: Part of the telomerase RNA 3' end complex which contains about
CC 488 proteins (By similarity). {ECO:0000250|UniProtKB:Q9BQ61}.
CC -!- DOMAIN: The C-terminus contains a key domain which is responsible for
CC the RNA digestion activity (By similarity).
CC {ECO:0000250|UniProtKB:Q9BQ61}.
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DR EMBL; AK003299; BAB22700.1; -; mRNA.
DR EMBL; AK009653; BAB26417.1; -; mRNA.
DR EMBL; BC023284; AAH23284.1; -; mRNA.
DR EMBL; BC029622; AAH29622.1; -; mRNA.
DR CCDS; CCDS22490.1; -.
DR RefSeq; NP_081036.2; NM_026760.2.
DR AlphaFoldDB; Q9D735; -.
DR BioGRID; 212918; 18.
DR IntAct; Q9D735; 1.
DR MINT; Q9D735; -.
DR STRING; 10090.ENSMUSP00000044129; -.
DR iPTMnet; Q9D735; -.
DR PhosphoSitePlus; Q9D735; -.
DR EPD; Q9D735; -.
DR MaxQB; Q9D735; -.
DR PaxDb; Q9D735; -.
DR PeptideAtlas; Q9D735; -.
DR PRIDE; Q9D735; -.
DR ProteomicsDB; 259102; -.
DR Antibodypedia; 26146; 34 antibodies from 15 providers.
DR DNASU; 68544; -.
DR Ensembl; ENSMUST00000047281; ENSMUSP00000044129; ENSMUSG00000041203.
DR GeneID; 68544; -.
DR KEGG; mmu:68544; -.
DR UCSC; uc009moy.1; mouse.
DR CTD; 79002; -.
DR MGI; MGI:1922833; Trir.
DR VEuPathDB; HostDB:ENSMUSG00000041203; -.
DR eggNOG; ENOG502S83W; Eukaryota.
DR GeneTree; ENSGT00390000012267; -.
DR HOGENOM; CLU_126877_0_0_1; -.
DR InParanoid; Q9D735; -.
DR OMA; GKGDAWS; -.
DR OrthoDB; 1538520at2759; -.
DR PhylomeDB; Q9D735; -.
DR TreeFam; TF323808; -.
DR BioGRID-ORCS; 68544; 22 hits in 73 CRISPR screens.
DR PRO; PR:Q9D735; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D735; protein.
DR Bgee; ENSMUSG00000041203; Expressed in dorsal pancreas and 265 other tissues.
DR Genevisible; Q9D735; MM.
DR GO; GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.
DR GO; GO:0008409; F:5'-3' exonuclease activity; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0090503; P:RNA phosphodiester bond hydrolysis, exonucleolytic; ISS:UniProtKB.
DR GO; GO:0016075; P:rRNA catabolic process; ISS:UniProtKB.
DR InterPro; IPR038838; TRIR.
DR PANTHER; PTHR34753; PTHR34753; 1.
PE 1: Evidence at protein level;
KW Acetylation; Exonuclease; Hydrolase; Nuclease; Reference proteome;
KW RNA-binding.
FT CHAIN 1..173
FT /note="Telomerase RNA component interacting RNase"
FT /id="PRO_0000280763"
FT REGION 1..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 143
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT CONFLICT 19..25
FT /note="AGSGRSR -> RGAAAGAE (in Ref. 1; BAB22700)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 173 AA; 18377 MW; DED242DABAD80D84 CRC64;
MAARGRRAEP PGREAPGPAG SGRSRWAESG PGTSPESGDD EVSGSSPVSS GVNLFANDGS
FLELFKRKME EEQRQRQEEP PPGPQRPDPP ASAAAGPGNP KRKGGPGPTL SFVGKRRGGN
KLALKTGIVA KKQKTEDEVL TSKGDAWAKY MAEVKKYKAH QCGDDDKTRP LVK
