TRISR_DROME
ID TRISR_DROME Reviewed; 669 AA.
AC Q9VML9; Q9VMM1;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 4.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Trissin receptor {ECO:0000312|FlyBase:FBgn0085410};
GN Name=TrissinR {ECO:0000312|FlyBase:FBgn0085410};
GN ORFNames=CG34381 {ECO:0000312|FlyBase:FBgn0085410};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:ACJ23469.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21939639; DOI=10.1016/j.bbrc.2011.09.018;
RA Ida T., Takahashi T., Tominaga H., Sato T., Kume K., Yoshizawa-Kumagaye K.,
RA Nishio H., Kato J., Murakami N., Miyazato M., Kangawa K., Kojima M.;
RT "Identification of the endogenous cysteine-rich peptide trissin, a ligand
RT for an orphan G protein-coupled receptor in Drosophila.";
RL Biochem. Biophys. Res. Commun. 414:44-48(2011).
CC -!- FUNCTION: G-protein coupled receptor which is activated by the Trissin
CC peptide in vitro, leading to increased intracellular calcium ion
CC levels. {ECO:0000269|PubMed:21939639}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:21939639};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AE014134; AAF52294.4; -; Genomic_DNA.
DR EMBL; BT050585; ACJ23469.1; -; mRNA.
DR RefSeq; NP_001097092.1; NM_001103622.2.
DR AlphaFoldDB; Q9VML9; -.
DR IntAct; Q9VML9; 2.
DR STRING; 7227.FBpp0111531; -.
DR GlyGen; Q9VML9; 4 sites.
DR PaxDb; Q9VML9; -.
DR DNASU; 33812; -.
DR EnsemblMetazoa; FBtr0112619; FBpp0111531; FBgn0085410.
DR GeneID; 33812; -.
DR KEGG; dme:Dmel_CG34381; -.
DR UCSC; CG34381-RA; d. melanogaster.
DR CTD; 33812; -.
DR FlyBase; FBgn0085410; TrissinR.
DR VEuPathDB; VectorBase:FBgn0085410; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q9VML9; -.
DR PhylomeDB; Q9VML9; -.
DR BioGRID-ORCS; 33812; 0 hits in 1 CRISPR screen.
DR ChiTaRS; TrissinR; fly.
DR GenomeRNAi; 33812; -.
DR PRO; PR:Q9VML9; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0085410; Expressed in oviduct (Drosophila) and 10 other tissues.
DR ExpressionAtlas; Q9VML9; differential.
DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:FlyBase.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IPI:FlyBase.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; ISM:FlyBase.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:FlyBase.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..669
FT /note="Trissin receptor"
FT /id="PRO_0000437961"
FT TOPO_DOM 1..184
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 185..205
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..217
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 218..238
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..269
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 270..290
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..302
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 303..323
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..350
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 351..371
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 372..552
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 553..573
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 574..595
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 596..616
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 617..669
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..430
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 257..340
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 669 AA; 74486 MW; 6A19AC090664A52B CRC64;
MIMTMMQTVR AWQQESDVEH RKQHKQRWRP DGAHISAAYD LNSDNDDGHH RVVHNQNNGS
PNSSPNQSTS AFRQRQPHHP PTGQQPPRLP CTVTHFSAHW KTLLILLTLL SASTLTASAN
VTSTISPPIN GSSTDYILLY GESTTSLVPA LTTGLSGDGS GAVIEDEEDA EKASEYIFDR
TDVRIIFITL YTLVFCCCFF GNLLVILVVT LSRRLRSITN FFLANLAFAD FCVGLFCVMQ
NLSIYLIESW VFGEFLCRMY QFVHSLSYTA SIFILVVICM ERYFAIVHPI TCKQILTAAR
LRMVIVTVWI TSAVYSTPKF VFSKTIKNIH TQDGQEEEIC VLDREMFNSK LLDMINFVLL
YVMPLLVMTV LYSKIAIALW RSSRGLTPHV VQHQHQQPQQ PSCQDIGMGM HNSMYHHHPH
HHHHHHQHHQ LQSAASSAGV VGVGLGGGGG GGPGPSLASG GSSTTSLSRK QSSKYEKRGV
SITESQLDNC KVSLEADRPI VSACRKTSFY HHGHAHHQRA GNASVGGGSG GAGAGATHMS
HSSSNVLRAR RGVVRMLIIF VLTFALCNLP YHARKMWQYW SRSYRGDSNF NALLTPLTFL
VTYFNSGVNP LLYAFLSRNF RKGMKELLLC SWKKGKGKSS SNSSMHHKRK ALQTHSLPTD
TTHIGNEQL
