TRK1_SACUV
ID TRK1_SACUV Reviewed; 1241 AA.
AC P28569;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=High-affinity potassium transport protein;
GN Name=TRK1;
OS Saccharomyces uvarum (Yeast) (Saccharomyces bayanus var. uvarum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=230603;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=R1668;
RX PubMed=2022322; DOI=10.1016/0378-1119(91)90031-6;
RA Anderson J.A., Best L.A., Gaber R.F.;
RT "Structural and functional conservation between the high-affinity K+
RT transporters of Saccharomyces uvarum and Saccharomyces cerevisiae.";
RL Gene 99:39-46(1991).
CC -!- FUNCTION: This protein is required for high-affinity potassium
CC transport.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the TrkH potassium transport family.
CC {ECO:0000305}.
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DR EMBL; M57508; AAA34661.1; -; Genomic_DNA.
DR AlphaFoldDB; P28569; -.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0030007; P:cellular potassium ion homeostasis; IEA:InterPro.
DR InterPro; IPR003445; Cat_transpt.
DR InterPro; IPR004773; K/Na_transp_Trk/HKT.
DR InterPro; IPR015958; Trk_fungi.
DR Pfam; PF02386; TrkH; 1.
DR PIRSF; PIRSF002450; K+_transpter_TRK; 1.
DR TIGRFAMs; TIGR00934; 2a38euk; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Ion transport; Membrane; Potassium; Potassium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1241
FT /note="High-affinity potassium transport protein"
FT /id="PRO_0000070460"
FT TRANSMEM 49..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 784..806
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 819..840
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 844..864
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 868..888
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 904..924
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 929..949
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 977..997
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1084..1104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1117..1137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 162..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1222..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..494
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..540
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1041
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 227
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 274
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 353
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 364
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 389
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 442
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 505
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 538
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 584
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 660
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 681
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 691
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 741
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 925
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1241 AA; 141226 MW; F5149E47EC00BCD2 CRC64;
MHIRGTMSRV PTLASFEVRY KKSFGHKFRD FIALCGHYCS PIKKYIFPNF IAVHYFYTIV
LTLITSILLY PVKNIRYIDA LFLAAGAVTQ GGLNTVDVNN LTLYQQIILY IICCISTPIA
VHSCLAFVRL YWFERYFDGI RDSSRLNFKM RRTKTILERE LTARTMTKSK TGGTQRVSRP
GKSDKRDDFQ EKLFNGEMVN RDEQDSVHSS HNSRDSNSNA NTNSSNNNSI NHNGSSGSLD
DYVREDKADE VEKYHGNKSY SSVGSSSNTA TDENISQKLK PSSLRFDESQ NKRKRTGAPS
EKFAKRRGSR DITPEDMYRS IMMLQGEHEG TAEDEGPPLV IGSPTDGTRN MDNGSESKSA
PTMNESKIRI QDKGAKISLD QDSVLHSSNS SACTSDEDSL PTNFGGTTPS LSAKPRESSS
GPIAFTEGEN ADRKQGPSIQ FNITKPPRKA SKSKRVSTMD DLNPRSIFPH QKKSSKGYIM
KHLPKARRIR QQIKRRLSTG SIDKNSSSDA LDRGLISGLN DDDDGNEGDN MEEYFADNES
GDEDDRMQQS EPQSGSELKL KQQQQHQLQQ NLHRMYKTKS FDDNRSKPVL MERSKTIDMA
EARDLNELAR TPDFQKMVYK NWKAHHRNKP NFKRRGWNGK MFEHGPYTSD SDHNYQDNGN
NSNSIVHYAE SILHRDNSHR NGSEDVSSDS NETTYPLNGN NDHSQNDANG YPTYNDEEEG
YYGLHFDSDY NLDPHHALSS NASKNYLSWQ PTIGRNSNFL GLTRAQKDEL GGVEYRAIKL
LCTILVVYYV GWHIVSFVML VPWINLKKHY SDIVRSDGVS PTWWGFWTAM SAFNDLGLTL
TPDSMMSFDK AVYPLIVMIW FIIIGNTGFP ILLRCIIWIM FKLSPDLSQM RESLGFLLDH
PRRCFTLLFP KAATWWLLLT LVGLNFTDWI LFIILDFGST VVKSLSKGYR VLVGLFQSVS
TRTAGFSVVD LSQLHPSIQV SYMLMMYVSV LPLAISIRRT NVYEEQSLGL YGEMGGKPED
TDTEEDGDCD DEDDDNEEEE SHEGGSSQRG KSKKETKKKK KRKENENPNE ESTKSFIGAH
LRRQLSFDLW FLFLGLFIIC ICERDKIKDI QRPNFNVFTI LFEIVSAYGT VGLSLGYPNT
NQSFSRQLTT LSKLIIIAML IRGKNRGLPY SLDRAIILPS DRLEHIDHIE DLKLKRQART
DTDDPMTEHL KRSISDAKHR WDELKHKRSL SRSSKRSTKT N
