ID   TRKA1_METMA             Reviewed;         448 AA.
AC   P0CW17; P39449;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Trk system potassium uptake protein TrkA homolog 1;
DE            Short=K(+)-uptake protein trkA homolog 1;
GN   Name=trkA1; Synonyms=trkA; OrderedLocusNames=MM_2503;
OS   Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS   11833 / OCM 88) (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=192952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX   PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA   Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA   Fritz H.-J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT   between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC   -!- FUNCTION: Part of a potassium transport system. {ECO:0000250}.
CC   -!- DOMAIN: The RCK N-terminal domain binds NAD and possibly other
CC       effectors. This is expected to cause a conformation change that
CC       regulates potassium transport (By similarity). {ECO:0000250}.
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DR   EMBL; AE008384; AAM32199.1; -; Genomic_DNA.
DR   RefSeq; WP_011034421.1; NC_003901.1.
DR   AlphaFoldDB; P0CW17; -.
DR   SMR; P0CW17; -.
DR   STRING; 192952.MM_2503; -.
DR   EnsemblBacteria; AAM32199; AAM32199; MM_2503.
DR   GeneID; 44088196; -.
DR   GeneID; 66135465; -.
DR   KEGG; mma:MM_2503; -.
DR   PATRIC; fig|192952.21.peg.2865; -.
DR   eggNOG; arCOG01959; Archaea.
DR   HOGENOM; CLU_046525_0_0_2; -.
DR   OMA; IACQVAY; -.
DR   Proteomes; UP000000595; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1450; -; 2.
DR   InterPro; IPR006036; K_uptake_TrkA.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF02080; TrkA_C; 2.
DR   Pfam; PF02254; TrkA_N; 2.
DR   PRINTS; PR00335; KUPTAKETRKA.
DR   SUPFAM; SSF116726; SSF116726; 2.
DR   SUPFAM; SSF51735; SSF51735; 2.
DR   PROSITE; PS51202; RCK_C; 2.
DR   PROSITE; PS51201; RCK_N; 2.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Potassium; Potassium transport; Reference proteome;
KW   Repeat; Transport.
FT   CHAIN           1..448
FT                   /note="Trk system potassium uptake protein TrkA homolog 1"
FT                   /id="PRO_0000408041"
FT   DOMAIN          2..132
FT                   /note="RCK N-terminal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          144..225
FT                   /note="RCK C-terminal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   DOMAIN          232..356
FT                   /note="RCK N-terminal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          368..448
FT                   /note="RCK C-terminal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   BINDING         7..11
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         29
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         70..71
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         101
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250"
FT   BINDING         232..262
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   448 AA;  48774 MW;  7B16E142CB28814B CRC64;
     MKAVIIGAGE VGYHIAKALS PKNDVVIIDK DEEAAKRADE LDVLVIEGNG ANAEILSRVL
     QNADLLVAVT GVDEVNIVAC MTAKLIMKNK NGWKDTKTIA RVSNPDYIDS PVTSRAQVGV
     DLMICPELAL ASEVADILSS PSAIDAEMFA EGKVRMTEFA ISPESKLVGK HMQDLKLADC
     CIVSAVFRED QIIIPHGDDL IKANDHMVVV GKPESMEDLE SVFGSKVSHR TRILLIGCGI
     VGMYLAKLID KEENADLRII EHSKSRCIEV AEILENALVL NGDGTDVSLL REENIEDMDV
     VVAVTDSDEK NLLCSLLAKQ LGAKKVIARA DRSDYLPLFE MVGIDMAVSP REATVNEVLK
     LTMGRGIQTL TTIEGERAEI IEYTASEKSR IVGKPLNKVK FPKGALINMV VRGKETIIPR
     GDFIVNEGDR VVIFSMASAA SEVEKYFK