ID   TRKA1_METMZ             Reviewed;         406 AA.
AC   P0CW16; P39449;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Trk system potassium uptake protein trkA homolog 1;
DE            Short=K(+)-uptake protein trkA homolog 1;
GN   Name=trkA1; Synonyms=trkA;
OS   Methanosarcina mazei (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=2209;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=S-6;
RX   PubMed=8268235; DOI=10.1016/0167-4781(93)90022-6;
RA   Macario A.J.L., Dugan C.B., Conway de Macario E.;
RT   "An archaeal trkA homolog near dnaK and dnaJ.";
RL   Biochim. Biophys. Acta 1216:495-498(1993).
CC   -!- FUNCTION: Part of a potassium transport system. {ECO:0000250}.
CC   -!- DOMAIN: The RCK N-terminal domain binds NAD and possibly other
CC       effectors. This is expected to cause a conformation change that
CC       regulates potassium transport (By similarity). {ECO:0000250}.
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DR   EMBL; X74307; CAA52360.1; -; Genomic_DNA.
DR   PIR; S39806; S39806.
DR   AlphaFoldDB; P0CW16; -.
DR   SMR; P0CW16; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1450; -; 1.
DR   InterPro; IPR006036; K_uptake_TrkA.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF02080; TrkA_C; 1.
DR   Pfam; PF02254; TrkA_N; 2.
DR   PRINTS; PR00335; KUPTAKETRKA.
DR   SUPFAM; SSF116726; SSF116726; 1.
DR   SUPFAM; SSF51735; SSF51735; 2.
DR   PROSITE; PS51202; RCK_C; 1.
DR   PROSITE; PS51201; RCK_N; 2.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Potassium; Potassium transport; Repeat; Transport.
FT   CHAIN           1..406
FT                   /note="Trk system potassium uptake protein trkA homolog 1"
FT                   /id="PRO_0000148723"
FT   DOMAIN          2..132
FT                   /note="RCK N-terminal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          144..225
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   DOMAIN          232..356
FT                   /note="RCK N-terminal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   BINDING         7..11
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         29
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         70..71
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         101
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250"
FT   BINDING         232..262
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   406 AA;  44059 MW;  B9280E31191DE434 CRC64;
     MKAVIIGAGE VGYHIAKALS PKNDVVIIDK DEEAAKRADE LDVLVIEGNG ANAEILSRVL
     QNADLLVAVT GVDEVNIVAC MTAKLIMKNK NGWKDTKTIA RVSNPDYIDS PVTSRAQVGV
     DLMICPELAL ASEVADILSS PSAIDAEMFA EGKVRMTEFA ISPESKLVGK HMQDLKLADC
     CIVSAVFRED QIIIPHGDDL IKANDHMVVV GKPESMEDLE SVFGSKVSHR TRILLIGCGI
     VGMYLAKLID KEENADLRII EHSKSRCIEV AEILENALVL NGDGTDVSLL REENIEDMDV
     VVAVTDSDEK NLLCSLLAKQ LGAKKVIARA DRSDYLPLFE MVGIDMAVSP REATVNEVLK
     LTMGRGIQTL TTIEGERAEI IEYTASEKSR IVGKPLNKVK FPKGAP