ID   TRKA2_METMA             Reviewed;         448 AA.
AC   P58936;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   26-JUL-2002, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Trk system potassium uptake protein TrkA homolog 2;
DE            Short=K(+)-uptake protein TrkA homolog 2;
GN   Name=trkA2; Synonyms=trkA; OrderedLocusNames=MM_2501;
OS   Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS   11833 / OCM 88) (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=192952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX   PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA   Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA   Fritz H.-J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT   between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC   -!- FUNCTION: Part of a potassium transport system. {ECO:0000250}.
CC   -!- DOMAIN: The RCK N-terminal domain binds NAD and possibly other
CC       effectors. This is expected to cause a conformation change that
CC       regulates potassium transport (By similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM32197.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE008384; AAM32197.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_015412586.1; NC_003901.1.
DR   AlphaFoldDB; P58936; -.
DR   SMR; P58936; -.
DR   STRING; 192952.MM_2501; -.
DR   EnsemblBacteria; AAM32197; AAM32197; MM_2501.
DR   GeneID; 44087894; -.
DR   GeneID; 66135463; -.
DR   KEGG; mma:MM_2501; -.
DR   PATRIC; fig|192952.21.peg.2863; -.
DR   eggNOG; arCOG01959; Archaea.
DR   HOGENOM; CLU_046525_0_0_2; -.
DR   OMA; PNTMVME; -.
DR   Proteomes; UP000000595; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1450; -; 2.
DR   InterPro; IPR006036; K_uptake_TrkA.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF02080; TrkA_C; 2.
DR   Pfam; PF02254; TrkA_N; 2.
DR   PRINTS; PR00335; KUPTAKETRKA.
DR   SUPFAM; SSF116726; SSF116726; 2.
DR   SUPFAM; SSF51735; SSF51735; 2.
DR   PROSITE; PS51202; RCK_C; 2.
DR   PROSITE; PS51201; RCK_N; 2.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Potassium; Potassium transport; Reference proteome;
KW   Repeat; Transport.
FT   CHAIN           1..448
FT                   /note="Trk system potassium uptake protein TrkA homolog 2"
FT                   /id="PRO_0000148724"
FT   DOMAIN          2..132
FT                   /note="RCK N-terminal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          144..225
FT                   /note="RCK C-terminal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   DOMAIN          232..356
FT                   /note="RCK N-terminal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          368..448
FT                   /note="RCK C-terminal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   BINDING         7..11
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         29
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         70..71
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         101
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250"
FT   BINDING         232..262
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   448 AA;  48910 MW;  29F275F3F0A0FBEA CRC64;
     MKAVVIGAGE VGYHIAKFLS LTHDVIVIEN DEDALRRADE LDVQVVEGNG ANADILASVL
     PDVDILVAVT GVDEVNIVAC MTAKLILRAH PGWKETKTIA RVSNPDYIDV PVTSRAQVGV
     DIMICPELAL ASEVAEVLSN PSAIDAEMFA GGKVQMMEFA IRPDNRLVGK RMQDIELEDC
     CIVSAIFRNN DIIIPHGDDF IKANDHMVVV GKPRAMADLE NVFGNEGPHR NRILLIGCGI
     VGFYLAKIID KDENADLKVI EYRKSRCIEV AEMLENALIL NGDGTDVNLL REENIEDMDV
     VIAVTDNDEK NLLCSLLAKQ MGAKKVIARA DRSDYVPLFE MVGIDIAVSP REATVNEVLK
     LTMGKGIEAL ATIEGEKAEI IEYTASGQSK IVGKPLSKIK FPKGAIVTMV VHDDDVIIPR
     GEFIIREGDR VIIFALSSAV RSVEKLFK