TRKA_ARCFU
ID TRKA_ARCFU Reviewed; 436 AA.
AC O29420;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Trk system potassium uptake protein TrkA homolog;
DE Short=K(+)-uptake protein TrkA homolog;
GN Name=trkA; OrderedLocusNames=AF_0838;
OS Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS 100126 / VC-16).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=224325;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA Smith H.O., Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
CC -!- FUNCTION: Part of a potassium transport system. {ECO:0000250}.
CC -!- DOMAIN: The RCK N-terminal domain binds NAD and possibly other
CC effectors. This is expected to cause a conformation change that
CC regulates potassium transport (By similarity). {ECO:0000250}.
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DR EMBL; AE000782; AAB90401.1; -; Genomic_DNA.
DR PIR; F69354; F69354.
DR RefSeq; WP_010878341.1; NC_000917.1.
DR AlphaFoldDB; O29420; -.
DR SMR; O29420; -.
DR STRING; 224325.AF_0838; -.
DR DNASU; 1484057; -.
DR EnsemblBacteria; AAB90401; AAB90401; AF_0838.
DR GeneID; 24794436; -.
DR KEGG; afu:AF_0838; -.
DR eggNOG; arCOG01959; Archaea.
DR HOGENOM; CLU_046525_0_0_2; -.
DR OMA; IACQVAY; -.
DR OrthoDB; 13082at2157; -.
DR PhylomeDB; O29420; -.
DR Proteomes; UP000002199; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1450; -; 2.
DR InterPro; IPR006036; K_uptake_TrkA.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR Pfam; PF02080; TrkA_C; 2.
DR Pfam; PF02254; TrkA_N; 2.
DR PRINTS; PR00335; KUPTAKETRKA.
DR SUPFAM; SSF116726; SSF116726; 2.
DR SUPFAM; SSF51735; SSF51735; 2.
DR PROSITE; PS51202; RCK_C; 2.
DR PROSITE; PS51201; RCK_N; 2.
PE 3: Inferred from homology;
KW Ion transport; NAD; Potassium; Potassium transport; Reference proteome;
KW Repeat; Transport.
FT CHAIN 1..436
FT /note="Trk system potassium uptake protein TrkA homolog"
FT /id="PRO_0000148722"
FT DOMAIN 2..126
FT /note="RCK N-terminal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT DOMAIN 138..219
FT /note="RCK C-terminal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT DOMAIN 224..347
FT /note="RCK N-terminal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT DOMAIN 356..436
FT /note="RCK C-terminal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT BINDING 7..11
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 29
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 71..72
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 95
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /ligand_note="ligand shared between dimeric partners"
FT /evidence="ECO:0000250"
FT BINDING 226..253
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="2"
FT /evidence="ECO:0000255"
SQ SEQUENCE 436 AA; 47365 MW; 5F5C0425BFA2B266 CRC64;
MRIVIAGAGE VGYHLAMSLA PNHDVIIIEK DVSRFERVSE LDVVAINGNA ANMKVLRDAG
VERADVFLAV TGNDEVNLLS GLAAKKVGAK NVIVRVENPE YVDRPIVKEH PLGYDVLICP
QLSLAQEAAR LIGIPGAIEV VTFSGGKVEM IELQVMEGSK ADGKAIADLY LPQNVVIASI
YRNGHIEIPR GDTVLRAGDR VAIVSKTEDV EMLKGIFGPP VTRRVTIFGA GTIGSYTAKI
LAKGMTSVKL IESSMERCEA LSGELEGVRI VCGDATDIEF LIEEEIGKSD AVLAATESDE
KNLLISLLSK NLGARIAIAK VEKREYVKLF EAVGVDVALN PRSVTYNEVS KLLRTMRIET
LAEIEGTAVV EVVVRNTRLV GKALKDLPLP KDAIIGAIVR GNECLIPRGD TTIEYEDRLL
VFAKWDEIEK IEEIFR
