ID   TRKA_HAEIN              Reviewed;         458 AA.
AC   P71354;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Trk system potassium uptake protein TrkA;
DE            Short=K(+)-uptake protein TrkA;
GN   Name=trkA; OrderedLocusNames=HI_0625;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Part of a potassium transport system. {ECO:0000250}.
CC   -!- DOMAIN: The RCK N-terminal domain binds NAD and possibly other
CC       effectors. This is expected to cause a conformation change that
CC       regulates potassium transport (By similarity). {ECO:0000250}.
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DR   EMBL; L42023; AAC22285.1; -; Genomic_DNA.
DR   RefSeq; NP_438785.1; NC_000907.1.
DR   RefSeq; WP_005694644.1; NC_000907.1.
DR   AlphaFoldDB; P71354; -.
DR   SMR; P71354; -.
DR   STRING; 71421.HI_0625; -.
DR   EnsemblBacteria; AAC22285; AAC22285; HI_0625.
DR   KEGG; hin:HI_0625; -.
DR   PATRIC; fig|71421.8.peg.651; -.
DR   eggNOG; COG0569; Bacteria.
DR   HOGENOM; CLU_046525_0_2_6; -.
DR   OMA; IACQVAY; -.
DR   PhylomeDB; P71354; -.
DR   BioCyc; HINF71421:G1GJ1-652-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IBA:GO_Central.
DR   Gene3D; 3.30.70.1450; -; 2.
DR   InterPro; IPR006036; K_uptake_TrkA.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF02080; TrkA_C; 2.
DR   Pfam; PF02254; TrkA_N; 2.
DR   PRINTS; PR00335; KUPTAKETRKA.
DR   SUPFAM; SSF116726; SSF116726; 2.
DR   SUPFAM; SSF51735; SSF51735; 2.
DR   PROSITE; PS51202; RCK_C; 2.
DR   PROSITE; PS51201; RCK_N; 2.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Potassium; Potassium transport; Reference proteome;
KW   Repeat; Transport.
FT   CHAIN           1..458
FT                   /note="Trk system potassium uptake protein TrkA"
FT                   /id="PRO_0000148715"
FT   DOMAIN          2..131
FT                   /note="RCK N-terminal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          143..227
FT                   /note="RCK C-terminal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   DOMAIN          234..356
FT                   /note="RCK N-terminal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          368..453
FT                   /note="RCK C-terminal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   BINDING         7..11
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         30
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         73..74
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         98
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250"
FT   BINDING         234..262
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   458 AA;  50174 MW;  E1FAB66AA1A221DA CRC64;
     MKIIILGAGQ VGTTLAENLV SEDNDITLVD NESPQLQTLQ EKHDLRVVQG SPSSPKVLRD
     AGAADADLMV AVTASDEINM VACQMGYTLF NTPTRIARIR NSEYLREKDK LFNNENIPID
     HLISPENLVT DEITRLIAYP GALQVAHFAN NRISIVVVKA YYGGALVGYA LSAFREHMPH
     IDCRIMSILR NGKPIRPQGS TIVEAGDEIT FICATEHIKA IMGELQRLEK PYKRVMIVGG
     GNVAFGVAKR LENSCTVKLI ERDSNRAQAL AEKLPKTLVF NGDASDQNLL FEEHIESVDV
     FLSLSSDDEA NIMSALLAKR LGAKKAMVLI QRIAYINLIQ GGTIDIAVSP QQVTISALLG
     HVRKGDVKNV ATLRHGIAEA IEIVAHGNVN TSNIVGRKIG ELRLPMGIII GALLRGNDVI
     IARRQVIIEE GDHIVIYLSD KKNVPEIEKL FQPSAFFI