ID   TRKA_METTH              Reviewed;         216 AA.
AC   O27333;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Trk system potassium uptake protein TrkA homolog;
DE            Short=K(+)-uptake protein TrkA homolog;
GN   Name=trkA; OrderedLocusNames=MTH_1265;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Part of a potassium transport system. {ECO:0000250}.
CC   -!- DOMAIN: The RCK N-terminal domain binds NAD and possibly other
CC       effectors. This is expected to cause a conformation change that
CC       regulates potassium transport (By similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB85754.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000666; AAB85754.1; ALT_INIT; Genomic_DNA.
DR   PIR; B69036; B69036.
DR   RefSeq; WP_048061014.1; NC_000916.1.
DR   AlphaFoldDB; O27333; -.
DR   SMR; O27333; -.
DR   STRING; 187420.MTH_1265; -.
DR   EnsemblBacteria; AAB85754; AAB85754; MTH_1265.
DR   GeneID; 24854386; -.
DR   KEGG; mth:MTH_1265; -.
DR   PATRIC; fig|187420.15.peg.1245; -.
DR   HOGENOM; CLU_046525_2_3_2; -.
DR   OMA; RWTADQM; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1450; -; 1.
DR   InterPro; IPR006036; K_uptake_TrkA.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF02080; TrkA_C; 1.
DR   Pfam; PF02254; TrkA_N; 1.
DR   PRINTS; PR00335; KUPTAKETRKA.
DR   SUPFAM; SSF116726; SSF116726; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51202; RCK_C; 1.
DR   PROSITE; PS51201; RCK_N; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Potassium; Potassium transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..216
FT                   /note="Trk system potassium uptake protein TrkA homolog"
FT                   /id="PRO_0000148726"
FT   DOMAIN          2..124
FT                   /note="RCK N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          136..216
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   BINDING         7..11
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         30
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         73..74
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         97
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   216 AA;  23253 MW;  E327BA8498EC8B4E CRC64;
     MYVVIMGGGR VGLTLANLLI SDGHDVTLIE NEETLCANAA VELDALVICG NGTDIKTLEE
     ANISNADVFV AATGNDEANL LSCILVREYS IPKIIARVSN PDHEEAFKKV GIDHVISPER
     TAAGYLEKLI TRPKVADLIV LGHGDAEILD MEIRSSKVVG KRVGDVSPTD KYIIVAIYNN
     GDLIIPQPDM VLERGTKVSV LVKTDAVKEA TRRFTG