TRKA_MYCTU
ID TRKA_MYCTU Reviewed; 220 AA.
AC P9WFZ3; L0TAC9; O07194;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Trk system potassium uptake protein TrkA;
DE Short=K(+)-uptake protein TrkA;
GN Name=trkA; Synonyms=ceoC; OrderedLocusNames=Rv2692; ORFNames=MTCY05A6.13;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-110.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9784509; DOI=10.1128/iai.66.11.5099-5106.1998;
RA Chen P., Bishai W.R.;
RT "Novel selection for isoniazid (INH) resistance genes supports a role for
RT NAD+-binding proteins in mycobacterial INH resistance.";
RL Infect. Immun. 66:5099-5106(1998).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: Part of a potassium transport system. {ECO:0000250}.
CC -!- DOMAIN: The RCK N-terminal domain binds NAD and possibly other
CC effectors. This is expected to cause a conformation change that
CC regulates potassium transport (By similarity). {ECO:0000250}.
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DR EMBL; AF026541; AAC69360.1; -; Genomic_DNA.
DR EMBL; AL123456; CCP45490.1; -; Genomic_DNA.
DR PIR; G70529; G70529.
DR RefSeq; WP_003899435.1; NZ_NVQJ01000017.1.
DR RefSeq; YP_177901.1; NC_000962.3.
DR AlphaFoldDB; P9WFZ3; -.
DR SMR; P9WFZ3; -.
DR STRING; 83332.Rv2692; -.
DR PaxDb; P9WFZ3; -.
DR DNASU; 887493; -.
DR GeneID; 887493; -.
DR KEGG; mtu:Rv2692; -.
DR TubercuList; Rv2692; -.
DR eggNOG; COG0569; Bacteria.
DR OMA; QRCNVVI; -.
DR PhylomeDB; P9WFZ3; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1450; -; 1.
DR InterPro; IPR006036; K_uptake_TrkA.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR PRINTS; PR00335; KUPTAKETRKA.
DR SUPFAM; SSF116726; SSF116726; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 1: Evidence at protein level;
KW Ion transport; NAD; Potassium; Potassium transport; Reference proteome;
KW Transport.
FT CHAIN 1..220
FT /note="Trk system potassium uptake protein TrkA"
FT /id="PRO_0000148720"
FT DOMAIN 2..125
FT /note="RCK N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT DOMAIN 137..218
FT /note="RCK C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT BINDING 7..11
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 30
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 50
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 72..73
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 97
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_note="ligand shared between dimeric partners"
FT /evidence="ECO:0000250"
SQ SEQUENCE 220 AA; 23947 MW; 0BD0D67845CE2685 CRC64;
MKVAVAGAGA VGRSVTRELV ENGHDITLIE RNPDHLDAAA IPEAHWRLGD ACELSLLESI
HLEEFDVVVA ATGDDKVNVV LSLLAKTEFA VPRVVARVND PRNEWLFNDA WGVDVAVSTP
RMLASLIEEA VTIGDLVRLM EFRTGQANLV EITLPDNTPW GGKPVRKLQL PRDAALVTIL
RGPRVIVPEA DEPLEGGDEL LFVAVTEAEE ELSRLLLPSM
