TRKA_PYRAB
ID TRKA_PYRAB Reviewed; 227 AA.
AC Q9UXU0; G8ZKV1;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Trk system potassium uptake protein TrkA homolog;
DE Short=K(+)-uptake protein TrkA homolog;
GN Name=trkA; OrderedLocusNames=PYRAB17680; ORFNames=PAB1178;
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay;
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=GE5 / Orsay;
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- FUNCTION: Part of a potassium transport system. {ECO:0000250}.
CC -!- DOMAIN: The RCK N-terminal domain binds NAD and possibly other
CC effectors. This is expected to cause a conformation change that
CC regulates potassium transport (By similarity). {ECO:0000250}.
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DR EMBL; AJ248288; CAB50673.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE71242.1; -; Genomic_DNA.
DR PIR; C75029; C75029.
DR RefSeq; WP_010868887.1; NC_000868.1.
DR AlphaFoldDB; Q9UXU0; -.
DR SMR; Q9UXU0; -.
DR STRING; 272844.PAB1178; -.
DR EnsemblBacteria; CAB50673; CAB50673; PAB1178.
DR GeneID; 1496071; -.
DR KEGG; pab:PAB1178; -.
DR PATRIC; fig|272844.11.peg.1887; -.
DR eggNOG; arCOG01957; Archaea.
DR HOGENOM; CLU_046525_2_2_2; -.
DR OMA; QRCNVVI; -.
DR OrthoDB; 116057at2157; -.
DR PhylomeDB; Q9UXU0; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1450; -; 1.
DR InterPro; IPR006036; K_uptake_TrkA.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR PRINTS; PR00335; KUPTAKETRKA.
DR SUPFAM; SSF116726; SSF116726; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Ion transport; NAD; Potassium; Potassium transport; Transport.
FT CHAIN 1..227
FT /note="Trk system potassium uptake protein TrkA homolog"
FT /id="PRO_0000148727"
FT DOMAIN 2..130
FT /note="RCK N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT DOMAIN 141..223
FT /note="RCK C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT BINDING 7..11
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 30
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 51
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 73..74
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_note="ligand shared between dimeric partners"
FT /note="in other chain"
FT /evidence="ECO:0000250"
FT BINDING 98
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_note="ligand shared between dimeric partners"
FT /evidence="ECO:0000250"
SQ SEQUENCE 227 AA; 25306 MW; AB1F77D51032ED63 CRC64;
MYIIIMGAGR IGTLVARMLE SEGHDVAIIE MNRERAREIS EYVSGLVIEG DATDQKVLEN
ANIKNADAFA ALTGRDDANI LACILAKHLN PKIMTILRIT DPGKKKIFEE VKELKRYFDI
VVSPEDIAAN YIFRTLVTPG FDRVLLPREG AEIIQFQVNE DCEVAGKPIK ELNLPKDSLI
IAVYDEKGNL VIPSGDTVIP KKGQVIIFAK NSALQDVKKI MEKKREE
