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TRKA_SALTI
ID   TRKA_SALTI              Reviewed;         458 AA.
AC   P0A2K0; P39445;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Trk system potassium uptake protein TrkA;
DE            Short=K(+)-uptake protein TrkA;
GN   Name=trkA; Synonyms=sapG; OrderedLocusNames=STY4388, t4095;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Part of the constitutive potassium transport systems TrkG and
CC       TrkH. May regulate the transport activity of TrkG and TrkH systems.
CC       Binds to NAD(+) and NADH. In Salmonella it is required for resistance
CC       to antimicrobial peptides (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Note=Peripherally bound to the inner side of the inner membrane via the
CC       TrkG and TrkH proteins. {ECO:0000250}.
CC   -!- DOMAIN: The RCK N-terminal domain binds NAD and possibly other
CC       effectors. This is expected to cause a conformation change that
CC       regulates potassium transport (By similarity). {ECO:0000250}.
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DR   EMBL; AL513382; CAD09176.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO71562.1; -; Genomic_DNA.
DR   RefSeq; NP_458490.1; NC_003198.1.
DR   RefSeq; WP_000691374.1; NZ_WSUR01000046.1.
DR   AlphaFoldDB; P0A2K0; -.
DR   SMR; P0A2K0; -.
DR   STRING; 220341.16505180; -.
DR   EnsemblBacteria; AAO71562; AAO71562; t4095.
DR   GeneID; 66757744; -.
DR   KEGG; stt:t4095; -.
DR   KEGG; sty:STY4388; -.
DR   PATRIC; fig|220341.7.peg.4484; -.
DR   eggNOG; COG0569; Bacteria.
DR   HOGENOM; CLU_046525_0_2_6; -.
DR   OMA; IACQVAY; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1450; -; 2.
DR   InterPro; IPR006036; K_uptake_TrkA.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF02080; TrkA_C; 2.
DR   Pfam; PF02254; TrkA_N; 2.
DR   PRINTS; PR00335; KUPTAKETRKA.
DR   SUPFAM; SSF116726; SSF116726; 2.
DR   SUPFAM; SSF51735; SSF51735; 2.
DR   PROSITE; PS51202; RCK_C; 2.
DR   PROSITE; PS51201; RCK_N; 2.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; NAD;
KW   Potassium; Potassium transport; Repeat; Transport.
FT   CHAIN           1..458
FT                   /note="Trk system potassium uptake protein TrkA"
FT                   /id="PRO_0000148716"
FT   DOMAIN          2..131
FT                   /note="RCK N-terminal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          143..227
FT                   /note="RCK C-terminal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   DOMAIN          234..356
FT                   /note="RCK N-terminal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          368..453
FT                   /note="RCK C-terminal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   BINDING         7..11
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         30
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         73..74
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         98
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250"
FT   BINDING         234..262
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   458 AA;  50369 MW;  75127E09DAE8EB3E CRC64;
     MKIIILGAGQ VGGTLAENLV GENNDITVVD TNGERLRSLQ DKFDLRVVQG HGSHPRVLRE
     AGADDADMLV AVTSSDETNM VACQVAYSLF NTPNRIARIR SPDYVRDADK LFHSEAVPID
     HLIAPEQLVI DNIYRLIEYP GALQVVNFAE GKVSLAVVKA YYGGPLIGNA LSTMREHMPH
     IDTRVAAIFR HDRPIRPQGS TIVEAGDEVF FIAASQHIRA VMSELQRLEK PYKRIMLVGG
     GNIGAGLARR LEKDYSVKLI ERDQQRAAEL AEKLQNTIVF FGDASDQELL AEEHIDQVDL
     FIAVTNDDEA NIMSAMLAKR MGAKKVMVLI QRRAYVDLVQ GSVIDIAISP QQATISALLS
     HVRKADIVGV SSLRRGVAEA IEAVAHGDES TSRVVGRVID EIKLPPGTII GAVVRGNDVM
     IANDNLRIEQ GDHVIMFLTD KKFITDVERL FQPSPFFL
 
 
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