ID   TRKA_STRCO              Reviewed;         223 AA.
AC   Q53949;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 2.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Trk system potassium uptake protein TrkA;
DE            Short=K(+)-uptake protein TrkA;
GN   Name=trkA; OrderedLocusNames=SCO5876; ORFNames=SC2E9.17c;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-183.
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=2294088; DOI=10.1128/jb.172.1.326-333.1990;
RA   Narva K.E., Feitelson J.S.;
RT   "Nucleotide sequence and transcriptional analysis of the redD locus of
RT   Streptomyces coelicolor A3(2).";
RL   J. Bacteriol. 172:326-333(1990).
CC   -!- FUNCTION: Part of a potassium transport system. {ECO:0000250}.
CC   -!- DOMAIN: The RCK N-terminal domain binds NAD and possibly other
CC       effectors. This is expected to cause a conformation change that
CC       regulates potassium transport (By similarity). {ECO:0000250}.
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DR   EMBL; AL939125; CAA16485.1; -; Genomic_DNA.
DR   EMBL; M29790; AAA88557.1; -; Genomic_DNA.
DR   PIR; T34828; T34828.
DR   RefSeq; NP_629998.1; NC_003888.3.
DR   RefSeq; WP_003973145.1; NZ_VNID01000007.1.
DR   AlphaFoldDB; Q53949; -.
DR   SMR; Q53949; -.
DR   STRING; 100226.SCO5876; -.
DR   PRIDE; Q53949; -.
DR   GeneID; 1101318; -.
DR   KEGG; sco:SCO5876; -.
DR   PATRIC; fig|100226.15.peg.5975; -.
DR   eggNOG; COG0569; Bacteria.
DR   HOGENOM; CLU_046525_2_4_11; -.
DR   InParanoid; Q53949; -.
DR   OMA; RWTADQM; -.
DR   PhylomeDB; Q53949; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1450; -; 1.
DR   InterPro; IPR006036; K_uptake_TrkA.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF02080; TrkA_C; 1.
DR   Pfam; PF02254; TrkA_N; 1.
DR   PRINTS; PR00335; KUPTAKETRKA.
DR   SUPFAM; SSF116726; SSF116726; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51202; RCK_C; 1.
DR   PROSITE; PS51201; RCK_N; 1.
PE   3: Inferred from homology;
KW   Ion transport; NAD; Potassium; Potassium transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..223
FT                   /note="Trk system potassium uptake protein TrkA"
FT                   /id="PRO_0000148721"
FT   DOMAIN          2..125
FT                   /note="RCK N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          133..215
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   BINDING         7..11
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         30
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         73..74
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT                   /evidence="ECO:0000250"
FT   BINDING         98
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   223 AA;  24154 MW;  67955F97BFF0BF8A CRC64;
     MHIVIMGCGR VGSALAQALE QQGHTVAVID RDPTSFRRLG SSFGGRRVTG IGFDQDTLRE
     AGIEEAGAFA AVSSGDNSNI IAARVAREMF GVENVAARIY DPRRAEVYQR LGIPTVATVR
     WTADQMLRRL LPSGAEPLWR DPTGGVQLAE VHTSSSWVGH KISRLQEETG VRVAFVTRLG
     EAILPSSQTV LQEGDLVHVM MRTDEVHKVE AAFAKGPEEE GGH