TRL11_ARATH
ID TRL11_ARATH Reviewed; 275 AA.
AC O64654; B3H436;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Thioredoxin-like 1-1, chloroplastic;
DE AltName: Full=Atypical cysteine/histidine-rich thioredoxin 4;
DE Short=AtACHT4;
DE AltName: Full=Lilium-type thioredoxin 1-1;
DE Flags: Precursor;
GN OrderedLocusNames=At1g08570; ORFNames=F22O13.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10498962; DOI=10.1016/s1360-1385(99)01475-2;
RA Meyer Y., Verdoucq L., Vignols F.;
RT "Plant thioredoxins and glutaredoxins: identity and putative roles.";
RL Trends Plant Sci. 4:388-394(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19825616; DOI=10.1093/mp/ssn076;
RA Chibani K., Wingsle G., Jacquot J.P., Gelhaye E., Rouhier N.;
RT "Comparative genomic study of the thioredoxin family in photosynthetic
RT organisms with emphasis on Populus trichocarpa.";
RL Mol. Plant 2:308-322(2009).
RN [7]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=19109414; DOI=10.1104/pp.108.128314;
RA Dangoor I., Peled-Zehavi H., Levitan A., Pasand O., Danon A.;
RT "A small family of chloroplast atypical thioredoxins.";
RL Plant Physiol. 149:1240-1250(2009).
CC -!- FUNCTION: Thiol-disulfide oxidoreductase that may participate in
CC various redox reactions. Possesses insulin disulfide bonds reducing
CC activity. {ECO:0000269|PubMed:19109414}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000269|PubMed:19109414}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O64654-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O64654-2; Sequence=VSP_039283;
CC -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
CC -!- CAUTION: The active site contains a CGGC motif wich differs from the
CC conserved CGPC motif. {ECO:0000305}.
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DR EMBL; AF144387; AAD35005.1; -; mRNA.
DR EMBL; AC003981; AAF99754.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28307.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28309.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28310.1; -; Genomic_DNA.
DR EMBL; AY034938; AAK59444.1; -; mRNA.
DR EMBL; AY063115; AAL34289.1; -; mRNA.
DR EMBL; AK318661; BAH56776.1; -; mRNA.
DR PIR; T00710; T00710.
DR RefSeq; NP_001117248.1; NM_001123776.1. [O64654-2]
DR RefSeq; NP_001117249.1; NM_001123777.1. [O64654-2]
DR RefSeq; NP_172333.1; NM_100730.4. [O64654-1]
DR AlphaFoldDB; O64654; -.
DR SMR; O64654; -.
DR STRING; 3702.AT1G08570.1; -.
DR PaxDb; O64654; -.
DR PRIDE; O64654; -.
DR EnsemblPlants; AT1G08570.1; AT1G08570.1; AT1G08570. [O64654-1]
DR EnsemblPlants; AT1G08570.3; AT1G08570.3; AT1G08570. [O64654-2]
DR EnsemblPlants; AT1G08570.4; AT1G08570.4; AT1G08570. [O64654-2]
DR GeneID; 837379; -.
DR Gramene; AT1G08570.1; AT1G08570.1; AT1G08570. [O64654-1]
DR Gramene; AT1G08570.3; AT1G08570.3; AT1G08570. [O64654-2]
DR Gramene; AT1G08570.4; AT1G08570.4; AT1G08570. [O64654-2]
DR KEGG; ath:AT1G08570; -.
DR Araport; AT1G08570; -.
DR TAIR; locus:2025625; AT1G08570.
DR eggNOG; KOG0907; Eukaryota.
DR HOGENOM; CLU_055041_1_1_1; -.
DR InParanoid; O64654; -.
DR PhylomeDB; O64654; -.
DR PRO; PR:O64654; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O64654; baseline and differential.
DR Genevisible; O64654; AT.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0031969; C:chloroplast membrane; IDA:TAIR.
DR GO; GO:0009570; C:chloroplast stroma; IDA:TAIR.
DR GO; GO:0016671; F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor; IDA:TAIR.
DR GO; GO:0045454; P:cell redox homeostasis; IBA:GO_Central.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chloroplast; Disulfide bond; Electron transport;
KW Plastid; Redox-active center; Reference proteome; Transit peptide;
KW Transport.
FT TRANSIT 1..72
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 73..275
FT /note="Thioredoxin-like 1-1, chloroplastic"
FT /id="PRO_0000120064"
FT DOMAIN 73..206
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT REGION 238..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 129
FT /note="Nucleophile"
FT /evidence="ECO:0000255"
FT ACT_SITE 132
FT /note="Nucleophile"
FT /evidence="ECO:0000255"
FT DISULFID 129..132
FT /note="Redox-active"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT VAR_SEQ 1..98
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:19423640"
FT /id="VSP_039283"
SQ SEQUENCE 275 AA; 30323 MW; 9FDF02EA341DC4A1 CRC64;
MTEVISKTSL FLGACGNHHR VDDFSFSPVS FGGFGLKKSF SCLKLKSQKP LRSVFYGKQI
VFGDSQDESF RRSSAITAQT TLRIGTAQKW WEKGLKDNMR EISSAQELVD SLTNAGDKLV
VVDFFSPGCG GCKALHPKIC QFAEMNPDVQ FLQVNYEEHK SMCYSLGVHV LPFFRFYRGS
QGRVCSFSCT NATIKKFRDA LAKHGPDRCS LGPTKGLEEK ELVALAANKE LNFTYTPKPV
PVEKEAATPD SNPSLPVPLP SMSSNDEKTL VSAGR
