ID   TRM11_CHICK             Reviewed;         461 AA.
AC   Q6YJI5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=tRNA (guanine(10)-N2)-methyltransferase homolog;
DE            EC=2.1.1.-;
DE   AltName: Full=tRNA guanosine-2'-O-methyltransferase TRM11 homolog;
GN   Name=TRMT11;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Chen Y., Huang C.-H.;
RT   "Molecular identification and conserved evolution of a novel RNA methylase
RT   protein gene in higher eukaryotic organisms.";
RL   Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC       tRNA methyltransferase complex that mediates the methylation of the
CC       guanosine nucleotide at position 10 (m2G10) in tRNAs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. TRM11 methyltransferase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00959}.
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DR   EMBL; AY139090; AAN34361.1; -; mRNA.
DR   RefSeq; NP_989699.1; NM_204368.1.
DR   AlphaFoldDB; Q6YJI5; -.
DR   SMR; Q6YJI5; -.
DR   STRING; 9031.ENSGALP00000023895; -.
DR   PaxDb; Q6YJI5; -.
DR   GeneID; 378793; -.
DR   KEGG; gga:378793; -.
DR   CTD; 60487; -.
DR   VEuPathDB; HostDB:geneid_378793; -.
DR   eggNOG; KOG2671; Eukaryota.
DR   InParanoid; Q6YJI5; -.
DR   OrthoDB; 924753at2759; -.
DR   PhylomeDB; Q6YJI5; -.
DR   PRO; PR:Q6YJI5; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008168; F:methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0004809; F:tRNA (guanine-N2-)-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR000241; RNA_methylase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR   Pfam; PF01170; UPF0020; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
DR   PROSITE; PS51627; SAM_MT_TRM11; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Reference proteome; RNA-binding;
KW   S-adenosyl-L-methionine; Transferase; tRNA processing; tRNA-binding.
FT   CHAIN           1..461
FT                   /note="tRNA (guanine(10)-N2)-methyltransferase homolog"
FT                   /id="PRO_0000328119"
SQ   SEQUENCE   461 AA;  52953 MW;  75888D5202BA50EC CRC64;
     MAAAGLALQR YLLLLAQEHL EFRLPEITSL LSLCGGQFSS QQEVCVNSPF WILNIPSEEM
     ARGLMRRTVC AKSIFELWGH GRSAGELYAS LKNYPTDKML PYLQPDSTYK IHIHTFNKTL
     TQAQKIKKID ALEFLPFSGK VNLKNPEHIF WILEDYGMDP NNVPEEPFDL YFGRWIADGQ
     RELIESYSIK KRHFIGNTSM DACLSFIMAN HGRVKPNDIV YDPFVGTGGL LISSAHFGAY
     VCGTGIDYNT IHGLGKASRK NQKWRGPDEN IRANLRQYGL EKYYLDALVS DSSRPIWRKG
     TLFDAIITDP PYGIREATRR TGSQKESVKS SERSTENHII ISSSYHLSDI FFDLLKFAAE
     YLVMGGRLVY WLPIYRPEYT EEIVPRHPCL KLISNCEQML SSHTSRRLIT MEKVKEFKDQ
     DQNSYLSDGQ YMPYKGHNSF REKYFSGVTK RIAKEEKDNQ K