ID   TRM11_PONAB             Reviewed;         463 AA.
AC   Q5R962;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=tRNA (guanine(10)-N2)-methyltransferase homolog;
DE            EC=2.1.1.-;
DE   AltName: Full=tRNA guanosine-2'-O-methyltransferase TRM11 homolog;
GN   Name=TRMT11;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC       tRNA methyltransferase complex that mediates the methylation of the
CC       guanosine nucleotide at position 10 (m2G10) in tRNAs. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TRMT112. {ECO:0000250|UniProtKB:Q7Z4G4}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. TRM11 methyltransferase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00959}.
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DR   EMBL; CR859531; CAH91698.1; -; mRNA.
DR   RefSeq; NP_001127452.1; NM_001133980.1.
DR   AlphaFoldDB; Q5R962; -.
DR   SMR; Q5R962; -.
DR   STRING; 9601.ENSPPYP00000019024; -.
DR   GeneID; 100174524; -.
DR   KEGG; pon:100174524; -.
DR   CTD; 60487; -.
DR   eggNOG; KOG2671; Eukaryota.
DR   InParanoid; Q5R962; -.
DR   OrthoDB; 924753at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR000241; RNA_methylase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR   Pfam; PF01170; UPF0020; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
DR   PROSITE; PS51627; SAM_MT_TRM11; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Methyltransferase; Reference proteome; RNA-binding;
KW   S-adenosyl-L-methionine; Transferase; tRNA processing; tRNA-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z4G4"
FT   CHAIN           2..463
FT                   /note="tRNA (guanine(10)-N2)-methyltransferase homolog"
FT                   /id="PRO_0000230290"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z4G4"
SQ   SEQUENCE   463 AA;  53379 MW;  C7A6AC1270807C9E CRC64;
     MALSCTLNRY LLLMAQEHLE FRLPEIKSLL SLFGGQFGSS QETFGKSPFW ILSIPSEDIA
     RNLMKRTVCA KSIFELWGHG QSPEELYSSL KNYPVEKMVP FLHSDSTYKI KIHTFNKTLT
     QEEKIKRIDA LEFLPFEGKV NLKKPQHVFS VLEDYGLDPN CIPENPHNIY FGRWIADGQR
     ELIESYSVKK RHFIGNTSMD AGLSFIMANH GKVKENDIVF DPFVGTGGLL IACAHFGAYV
     YGTDIDYNTV HGLGKATRKN QKWRGPDENI RANLRQYGLE KYYLDVLVSD ASKPSWRKGT
     YFDAIITDPP YGIRESTRRT GSQKEIPKGI EKWEKCPESH VPVSLSYHLS DMFLDLLNFA
     AETLVLGGRL VYWLPVYTPE YTEEMVPWHP CLELISNCEQ KLSSHTSRRL ITMEKVKKFE
     NRDQYSHLLS DHFLPYQGHN SFREKYFSGV TKRIAKEEKS TQE