ID   TRM11_XENLA             Reviewed;         478 AA.
AC   Q6NS23;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=tRNA (guanine(10)-N2)-methyltransferase homolog;
DE            EC=2.1.1.-;
DE   AltName: Full=tRNA guanosine-2'-O-methyltransferase TRM11 homolog;
GN   Name=trmt11;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC       tRNA methyltransferase complex that mediates the methylation of the
CC       guanosine nucleotide at position 10 (m2G10) in tRNAs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. TRM11 methyltransferase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00959}.
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DR   EMBL; BC070528; AAH70528.1; -; mRNA.
DR   RefSeq; NP_001084954.1; NM_001091485.1.
DR   AlphaFoldDB; Q6NS23; -.
DR   SMR; Q6NS23; -.
DR   MaxQB; Q6NS23; -.
DR   DNASU; 432012; -.
DR   GeneID; 432012; -.
DR   KEGG; xla:432012; -.
DR   CTD; 432012; -.
DR   OrthoDB; 924753at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 432012; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR000241; RNA_methylase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR   Pfam; PF01170; UPF0020; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
DR   PROSITE; PS51627; SAM_MT_TRM11; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Reference proteome; RNA-binding;
KW   S-adenosyl-L-methionine; Transferase; tRNA processing; tRNA-binding.
FT   CHAIN           1..478
FT                   /note="tRNA (guanine(10)-N2)-methyltransferase homolog"
FT                   /id="PRO_0000328120"
FT   REGION          457..478
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   478 AA;  54965 MW;  36DAC17770A383C2 CRC64;
     MALPCKTGAA FKKYLLLLAQ ENCEFRLPEI KSLLSLYGGH FNNLQDEHGK SPFCILNLPS
     EEMARKLMKR TVCAKSVFEL WGHGKTFMEF QQSVLSYPLE NMMSYLQPNS TYKIIIHSFN
     KTLTQKEKLE KINTMEFIPF QGKVNLQNAE NIFYLLEDYG SDPNKAPNEP FEIFFGRWIA
     DGQRELINSY SVKKRHFIGN TSMDAGLSFI MANHARVKPN DVVFDPFVGT GGLLVSSAHF
     GAYVCGTEID YNTVHGLGKA TRMNQKWRGP DENIRANLRQ YGLEKYYLDV LVSDASKPVW
     RKAPLFDAII TDPPYGIRES TRKTGTQKEI IKTELFPESH VPVQLNYHLS DIFSDLFAFA
     SEFLVTGGRL VYWLPVYRPE YTEEVLPRHP CLKLISNCEQ MLSSHTSRRL ITMEKVKEFE
     EKYQYAHLGE GQNLPYKGHN SFREKYFSGL KKRTAREERA RSEMANAENV KSKGKEDV