ID   TRM1L_BOVIN             Reviewed;         737 AA.
AC   A5D7S3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=TRMT1-like protein;
DE            EC=2.1.1.-;
GN   Name=TRMT1L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in motor coordination and exploratory
CC       behavior. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Trm1 family. {ECO:0000255|PROSITE-ProRule:PRU00958}.
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DR   EMBL; BC140663; AAI40664.1; -; mRNA.
DR   RefSeq; NP_001091590.1; NM_001098121.1.
DR   AlphaFoldDB; A5D7S3; -.
DR   SMR; A5D7S3; -.
DR   STRING; 9913.ENSBTAP00000014994; -.
DR   PaxDb; A5D7S3; -.
DR   PRIDE; A5D7S3; -.
DR   Ensembl; ENSBTAT00000014994; ENSBTAP00000014994; ENSBTAG00000011285.
DR   GeneID; 540872; -.
DR   KEGG; bta:540872; -.
DR   CTD; 81627; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011285; -.
DR   VGNC; VGNC:36371; TRMT1L.
DR   eggNOG; KOG1253; Eukaryota.
DR   GeneTree; ENSGT00530000063646; -.
DR   InParanoid; A5D7S3; -.
DR   OrthoDB; 1414511at2759; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000011285; Expressed in spermatid and 107 other tissues.
DR   ExpressionAtlas; A5D7S3; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004809; F:tRNA (guanine-N2-)-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR   GO; GO:0002940; P:tRNA N2-guanine methylation; IBA:GO_Central.
DR   Gene3D; 3.30.56.70; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002905; Trm1.
DR   InterPro; IPR042296; tRNA_met_Trm1_C.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR10631; PTHR10631; 1.
DR   Pfam; PF02005; TRM; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51626; SAM_MT_TRM1; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Behavior; Isopeptide bond; Metal-binding; Methyltransferase;
KW   Phosphoprotein; Reference proteome; RNA-binding; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing; tRNA-binding; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..737
FT                   /note="TRMT1-like protein"
FT                   /id="PRO_0000317567"
FT   DOMAIN          233..692
FT                   /note="Trm1 methyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00958"
FT   ZN_FING         190..212
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         24
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   MOD_RES         72
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   MOD_RES         616
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   CROSSLNK        589
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
SQ   SEQUENCE   737 AA;  81813 MW;  F891CCCD0CA476F3 CRC64;
     MENMAEEELL PQEKVEVVQV PVPTPTPDSA RVPAPAPDSA PVSASTPAPA SAPTPASAPV
     PAPALAQASA LSPSLASAPD EAESKRHISI QRQLADLEKL AFVTEGDCDS ANSLNSDNLD
     AGNKQACPLC PKEKFRACNS HKLHRHLQNL HWKVSVEFEG YRMCICHLPC RPVKPNIIGE
     QISSKMGAHY HCIICSATIT RRTDMLGHVR RHVNKGETKS RYIAASAAKP PKEILKEADT
     DVQVCPNYTV PQKTDSYFNP KMKLNRQLIF CTLAALAKER KPLECLDAFG ATGIMGLQWA
     KHLGNAVKVT INDLNENSVT LIQENCHLNK LKVVVDSKEK EEREDILEEG EENLGNIKVT
     KMDANVLMHL RSFDFIHLDP FGTSVNYLDS AFRNIRNLGI VSVTSTDISS LYAKAQHVAR
     RHYGCNIVRT EYYKELAARI VVAAVARAAA RCNKGIEVLF AVALEHFVLV VVRVLRGPTS
     ADETAKKIQY LIHCQWCEER IFQKDGNMVE ENPYRQLPCN CHGSMPGKTA IELGPLWSSS
     LFNTGFLKRM LSESLHHGLD DIQTLIKTLI FESECTPQFS VHAPSNLNKP EECGVFIKTT
     DDTTTDSHSA QGKRKSNETT ANLVKRQKTD VNTEHPPFYY NIHRHSIKGM NMPKLKKFLC
     YLSQAGFRVS RTHFDPMGVR TDAPLMQFKS ILLKYSTPTY TGGQSEGHVQ PASEDTVADR
     VEMSVNDKAE AGGCRRW