TRM1L_MACFA
ID TRM1L_MACFA Reviewed; 693 AA.
AC Q4R6C7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=TRMT1-like protein;
DE EC=2.1.1.-;
GN Name=TRMT1L; ORFNames=QtsA-18292;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in motor coordination and exploratory
CC behavior. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Trm1 family. {ECO:0000255|PROSITE-ProRule:PRU00958}.
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DR EMBL; AB169258; BAE01348.1; -; mRNA.
DR RefSeq; NP_001270723.1; NM_001283794.1.
DR AlphaFoldDB; Q4R6C7; -.
DR SMR; Q4R6C7; -.
DR STRING; 9541.XP_005540295.1; -.
DR GeneID; 101865312; -.
DR CTD; 81627; -.
DR eggNOG; KOG1253; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004809; F:tRNA (guanine-N2-)-methyltransferase activity; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR Gene3D; 3.30.56.70; -; 1.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002905; Trm1.
DR InterPro; IPR042296; tRNA_met_Trm1_C.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10631; PTHR10631; 1.
DR Pfam; PF02005; TRM; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF53335; SSF53335; 1.
DR PROSITE; PS51626; SAM_MT_TRM1; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Behavior; Isopeptide bond; Metal-binding; Methyltransferase;
KW Phosphoprotein; Reference proteome; RNA-binding; S-adenosyl-L-methionine;
KW Transferase; tRNA processing; tRNA-binding; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..693
FT /note="TRMT1-like protein"
FT /id="PRO_0000317569"
FT DOMAIN 187..648
FT /note="Trm1 methyltransferase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00958"
FT ZN_FING 144..166
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOD_RES 572
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT MOD_RES 667
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT CROSSLNK 545
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
SQ SEQUENCE 693 AA; 78261 MW; C7977AF189897EAC CRC64;
MENMAEEELL PLEKEEVEVA QVQVQVPSLA SAPEEAKSKR HISIQRQLAD LEKLAFVTEG
NFDSTSSLNS DNLDAGNRQA CPLCPKEKFR ACNSHKLRRH LQNLHWKVSV EFEGYRMCIC
HLPCRPVKPN IIGEQISSKM GAHYHCIICS ATITRRTDML GHVRRHMNKG ETKSSYIAAS
TAKPPKEILK EADTDVQVCP NYSIPQKTDS YFNPKMKLNR QLIFCTLAAL AEERKPLECL
DAFGATGIMG LQWAKHLGNA VKVTINDLNE NSVTLIQENC YLNKLKVVVD SKEKEKSDDI
LEEGEKNIGN IKVTKMDANV LMHLRSFDFI HLDPFGTSVN YLDSAFRNIR NLGIVSVTST
DISSLYAKAQ HVARRHYGCN IVRTEYYKEL AARIVVAAVA RAAARCNKGI EVLFAVALEH
FVLVVVRVLR GPTSADETAK KIQYLIHCQW CEERIFQKDG NMVEENPYRQ LPCNCHGSMP
GKTAIELGPL WSSSLFNTGF LKRMLFESLH HGLDDIQTLI KTLIFESECT PQSQFSIHTP
SNLNKQEENG VFIKTTDDTI TDNYIAQGKR KSNEMITNLG KKQKTDVSTE HPPFYYNIHR
HSIKGMNMPK LKKFLCYLSQ AGFRVSRTHF DPMGVRTDAP LMQFKSILLK YSTPTYTGGQ
SESLVQSASE DTVTERVEMS VNDKAEASGC RRW