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TRM1L_MACFA
ID   TRM1L_MACFA             Reviewed;         693 AA.
AC   Q4R6C7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=TRMT1-like protein;
DE            EC=2.1.1.-;
GN   Name=TRMT1L; ORFNames=QtsA-18292;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in motor coordination and exploratory
CC       behavior. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Trm1 family. {ECO:0000255|PROSITE-ProRule:PRU00958}.
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DR   EMBL; AB169258; BAE01348.1; -; mRNA.
DR   RefSeq; NP_001270723.1; NM_001283794.1.
DR   AlphaFoldDB; Q4R6C7; -.
DR   SMR; Q4R6C7; -.
DR   STRING; 9541.XP_005540295.1; -.
DR   GeneID; 101865312; -.
DR   CTD; 81627; -.
DR   eggNOG; KOG1253; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004809; F:tRNA (guanine-N2-)-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.56.70; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002905; Trm1.
DR   InterPro; IPR042296; tRNA_met_Trm1_C.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR10631; PTHR10631; 1.
DR   Pfam; PF02005; TRM; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51626; SAM_MT_TRM1; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Behavior; Isopeptide bond; Metal-binding; Methyltransferase;
KW   Phosphoprotein; Reference proteome; RNA-binding; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing; tRNA-binding; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..693
FT                   /note="TRMT1-like protein"
FT                   /id="PRO_0000317569"
FT   DOMAIN          187..648
FT                   /note="Trm1 methyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00958"
FT   ZN_FING         144..166
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   MOD_RES         572
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   MOD_RES         667
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   CROSSLNK        545
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
SQ   SEQUENCE   693 AA;  78261 MW;  C7977AF189897EAC CRC64;
     MENMAEEELL PLEKEEVEVA QVQVQVPSLA SAPEEAKSKR HISIQRQLAD LEKLAFVTEG
     NFDSTSSLNS DNLDAGNRQA CPLCPKEKFR ACNSHKLRRH LQNLHWKVSV EFEGYRMCIC
     HLPCRPVKPN IIGEQISSKM GAHYHCIICS ATITRRTDML GHVRRHMNKG ETKSSYIAAS
     TAKPPKEILK EADTDVQVCP NYSIPQKTDS YFNPKMKLNR QLIFCTLAAL AEERKPLECL
     DAFGATGIMG LQWAKHLGNA VKVTINDLNE NSVTLIQENC YLNKLKVVVD SKEKEKSDDI
     LEEGEKNIGN IKVTKMDANV LMHLRSFDFI HLDPFGTSVN YLDSAFRNIR NLGIVSVTST
     DISSLYAKAQ HVARRHYGCN IVRTEYYKEL AARIVVAAVA RAAARCNKGI EVLFAVALEH
     FVLVVVRVLR GPTSADETAK KIQYLIHCQW CEERIFQKDG NMVEENPYRQ LPCNCHGSMP
     GKTAIELGPL WSSSLFNTGF LKRMLFESLH HGLDDIQTLI KTLIFESECT PQSQFSIHTP
     SNLNKQEENG VFIKTTDDTI TDNYIAQGKR KSNEMITNLG KKQKTDVSTE HPPFYYNIHR
     HSIKGMNMPK LKKFLCYLSQ AGFRVSRTHF DPMGVRTDAP LMQFKSILLK YSTPTYTGGQ
     SESLVQSASE DTVTERVEMS VNDKAEASGC RRW
 
 
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