ID   TRM1L_PONAB             Reviewed;         733 AA.
AC   Q5R5T0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=TRMT1-like protein;
DE            EC=2.1.1.-;
GN   Name=TRMT1L;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in motor coordination and exploratory
CC       behavior. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Trm1 family. {ECO:0000255|PROSITE-ProRule:PRU00958}.
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DR   EMBL; CR860774; CAH92886.1; -; mRNA.
DR   RefSeq; NP_001126691.1; NM_001133219.1.
DR   AlphaFoldDB; Q5R5T0; -.
DR   SMR; Q5R5T0; -.
DR   STRING; 9601.ENSPPYP00000000472; -.
DR   GeneID; 100173691; -.
DR   KEGG; pon:100173691; -.
DR   CTD; 81627; -.
DR   eggNOG; KOG1253; Eukaryota.
DR   InParanoid; Q5R5T0; -.
DR   OrthoDB; 1414511at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004809; F:tRNA (guanine-N2-)-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.56.70; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002905; Trm1.
DR   InterPro; IPR042296; tRNA_met_Trm1_C.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR10631; PTHR10631; 1.
DR   Pfam; PF02005; TRM; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51626; SAM_MT_TRM1; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Behavior; Isopeptide bond; Metal-binding; Methyltransferase;
KW   Phosphoprotein; Reference proteome; RNA-binding; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing; tRNA-binding; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..733
FT                   /note="TRMT1-like protein"
FT                   /id="PRO_0000317571"
FT   DOMAIN          227..688
FT                   /note="Trm1 methyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00958"
FT   ZN_FING         184..206
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         26
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   MOD_RES         66
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   MOD_RES         612
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   MOD_RES         707
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   CROSSLNK        585
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
SQ   SEQUENCE   733 AA;  81833 MW;  9DC8215A28584120 CRC64;
     MENMAEEELL PLEKEEVEVA QVQVPTPARD SAGVPAPAPD SALDSAPTPA SAPAPAPALA
     QAPALSPSLA SAPEEAKSKR HISIQRQLAD LEKLAFVTEG NFDSASSLNS DNLDAGNRQA
     CPLCPKEKFR ACNSHKLRRH LQNLHWKVSV EFEGYRMCIC HLPCRPVKPN IIGEQITSKM
     GAHYHCIICS ATITRRTDML GHVRRHMNKG ETKSSYVAAS TAKPPKEILK EADTDVQVCP
     NYSIPQKTDS YFNPKMKLNR LLIFCTLAAL AEERKPLECL DAFGATGIMG LQWAKHLGNA
     VRVTINDLNE NSVTLIQENC HLNKLKVMVD SKEKEKSDDI FEEGEKNLGN IKVTKMDANV
     LMHLRSFDFI HLDPFGTSVN YLDSAFRNIR NLGIVSVTST DISSLYAKAQ HVARRHYGCN
     IVRTEYYKEL AARIVVAAVA RAAARCNKGI EVLFAVALEH FVLVVVRVLR GPTSADETAK
     KIQYLIHCQW CEERIFQKDG NMVEENPYRQ LPCNCHGSMP GKTAIELGPL WSSSLFNTGF
     LKRMLFESLH HGLDDIQTLI KTLIFESECT PQSQFSIHAP SNLNKQEENG VFIKTTDDTT
     TDNYIAQGKR KSNEVITNLG KKQKTDVSTE HPPFYYNIHR HSIKGMNMPK LKKFLCYLSQ
     AGFRVSRTHF DPMGVRTDAP LMQFKSILLK YSTPTYTGGQ SESHVQSASE DTVTERVEMS
     VNDKAEASGC RRW