ID   TRM1L_RAT               Reviewed;         723 AA.
AC   Q496Z9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=TRMT1-like protein;
DE            EC=2.1.1.-;
GN   Name=Trmt1l;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in motor coordination and exploratory
CC       behavior. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. Trm1 family. {ECO:0000255|PROSITE-ProRule:PRU00958}.
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DR   EMBL; BC100650; AAI00651.1; -; mRNA.
DR   RefSeq; NP_001032269.1; NM_001037192.1.
DR   AlphaFoldDB; Q496Z9; -.
DR   SMR; Q496Z9; -.
DR   STRING; 10116.ENSRNOP00000003517; -.
DR   iPTMnet; Q496Z9; -.
DR   PhosphoSitePlus; Q496Z9; -.
DR   PaxDb; Q496Z9; -.
DR   PRIDE; Q496Z9; -.
DR   GeneID; 304851; -.
DR   KEGG; rno:304851; -.
DR   UCSC; RGD:1307890; rat.
DR   CTD; 81627; -.
DR   RGD; 1307890; Trmt1l.
DR   VEuPathDB; HostDB:ENSRNOG00000002580; -.
DR   eggNOG; KOG1253; Eukaryota.
DR   HOGENOM; CLU_010862_3_0_1; -.
DR   InParanoid; Q496Z9; -.
DR   OMA; MIRENCQ; -.
DR   OrthoDB; 1414511at2759; -.
DR   PhylomeDB; Q496Z9; -.
DR   PRO; PR:Q496Z9; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000002580; Expressed in quadriceps femoris and 19 other tissues.
DR   Genevisible; Q496Z9; RN.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004809; F:tRNA (guanine-N2-)-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030534; P:adult behavior; ISO:RGD.
DR   GO; GO:0008344; P:adult locomotory behavior; ISO:RGD.
DR   GO; GO:0002940; P:tRNA N2-guanine methylation; IBA:GO_Central.
DR   Gene3D; 3.30.56.70; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR002905; Trm1.
DR   InterPro; IPR042296; tRNA_met_Trm1_C.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR10631; PTHR10631; 1.
DR   Pfam; PF02005; TRM; 2.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS51626; SAM_MT_TRM1; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   2: Evidence at transcript level;
KW   Behavior; Isopeptide bond; Metal-binding; Methyltransferase;
KW   Phosphoprotein; Reference proteome; RNA-binding; S-adenosyl-L-methionine;
KW   Transferase; tRNA processing; tRNA-binding; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..723
FT                   /note="TRMT1-like protein"
FT                   /id="PRO_0000317572"
FT   DOMAIN          220..679
FT                   /note="Trm1 methyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00958"
FT   ZN_FING         177..199
FT                   /note="C2H2-type"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         23
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   MOD_RES         61
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   MOD_RES         603
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
FT   CROSSLNK        576
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z2T5"
SQ   SEQUENCE   723 AA;  80184 MW;  59451370C44BB9E9 CRC64;
     MENMAEEELL PQEKEEAQVR VPTPDSAPVP APAADTALDS APTPDSAPAP ALAPAPAPAL
     SPSLASVPEE AESKRHISIQ RRLADLEKLA FGTEGDVDSA SSLNSDNLEN IQTCPLCPKE
     KFRAYSSHKL RRHLQNLHWK ISVEFEGSRM CICHLACRPV KPTIVGEQIS SKLGAHYHCI
     ICSATITRRT DMLGHVKRHV NKGETKSRYI SASTAKSSNE VLKETDTDIQ VFPNYSIPQK
     TDSYFNPKMK LNRQIIFCTL AALAEERKPL ECLDAFGATG IMGLQWAKHL GNAVKVTIND
     LNENSVTLIQ KNCHLNKLKV VVDSEEKEEG DGLEDCSTAG DIQVTRMDAN VLMHLRSFDF
     IHLDPFGTSV NYLDSAFRNV RNLGIVSVTS TDISSLYAKA QHVARRHYGC NIVRTEYYKE
     LAARIVVAAV ARAAARCNKG VEVLFAVALE HFVLVVVRVL RGPTSADETA KKIQYLIHCQ
     WCEERIFQKD GNMVEENPYK QLPCNCHGSM PGKTAIELGP LWSSSLFNTG FLKRMLFESI
     HHGLDDIQPL IKTLIFESEC TPQSQCSVHA PSNTNKQEEN GVFVKTTDDT TIDIYSAQGK
     RKSNEMAINV AKKQKTDAST AHPPFYYNIH RHSIKGMNMP KLKKFLCCLS QAGFRVSRTH
     FDPMGIRTDA SLTQFKSILL KYSTPTYTGG QSEGQVPAPE DTVTDPVELS VNDKAEVSGC
     RRW