ID   TRM2_GAHVM              Reviewed;         134 AA.
AC   Q9E6N6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   02-DEC-2020, entry version 61.
DE   RecName: Full=Tripartite terminase subunit 2 {ECO:0000255|HAMAP-Rule:MF_04015};
GN   Name=TRM2 {ECO:0000255|HAMAP-Rule:MF_04015}; OrderedLocusNames=MDV045;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Component of the molecular motor that translocates viral
CC       genomic DNA in empty capsid during DNA packaging. Forms a tripartite
CC       terminase complex together with TRM1 and TRM3 in the host cytoplasm.
CC       Once the complex reaches the host nucleus, it interacts with the capsid
CC       portal vertex. This portal forms a ring in which genomic DNA is
CC       translocated into the capsid. {ECO:0000255|HAMAP-Rule:MF_04015}.
CC   -!- SUBUNIT: Associates with TRM1 and TRM3 to form the tripartite terminase
CC       complex. {ECO:0000255|HAMAP-Rule:MF_04015}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04015}.
CC       Note=Found associated with the external surface of the viral capsid
CC       during assembly and DNA packaging, but seems absent in extracellular
CC       mature virions. {ECO:0000255|HAMAP-Rule:MF_04015}.
CC   -!- SIMILARITY: Belongs to the herpesviridae TRM2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04015}.
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DR   EMBL; AF243438; AAG14225.1; -; Genomic_DNA.
DR   RefSeq; YP_001033962.1; NC_002229.3.
DR   SMR; Q9E6N6; -.
DR   GeneID; 4811508; -.
DR   KEGG; vg:4811508; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019073; P:viral DNA genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04015; HSV_TRM2; 1.
DR   InterPro; IPR005208; Herpes_TT2.
DR   Pfam; PF03581; Herpes_UL33; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome; Viral genome packaging;
KW   Viral release from host cell.
FT   CHAIN           1..134
FT                   /note="Tripartite terminase subunit 2"
FT                   /id="PRO_0000406547"
SQ   SEQUENCE   134 AA;  15301 MW;  C9C0DA120BE3BFB4 CRC64;
     MAGENTSRRT GSARLDEVIP EFELVSTDVK ILAEKYLQDE RIYRIWFEYL IPDEIDLIFP
     TTDGKLNYLS FTKRLASAIR YGRIKTAVSN NSSSNSYGST EHVCDHGTSL CGRSERFASV
     INRFLDLHQI LKDC