ID   TRM2_HHV2H              Reviewed;         130 AA.
AC   P89456;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   02-JUN-2021, entry version 66.
DE   RecName: Full=Tripartite terminase subunit 2 {ECO:0000255|HAMAP-Rule:MF_04015};
GN   Name=TRM2 {ECO:0000255|HAMAP-Rule:MF_04015}; OrderedLocusNames=UL33;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1662697; DOI=10.1099/0022-1317-72-12-3057;
RA   McGeoch D.J., Cunningham C., McIntyre G., Dolan A.;
RT   "Comparative sequence analysis of the long repeat regions and adjoining
RT   parts of the long unique regions in the genomes of herpes simplex viruses
RT   types 1 and 2.";
RL   J. Gen. Virol. 72:3057-3075(1991).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=11161269; DOI=10.1099/0022-1317-82-2-321;
RA   Yamauchi Y., Wada K., Goshima F., Takakuwa H., Daikoku T., Yamada M.,
RA   Nishiyama Y.;
RT   "The UL14 protein of herpes simplex virus type 2 translocates the minor
RT   capsid protein VP26 and the DNA cleavage and packaging UL33 protein into
RT   the nucleus of coexpressing cells.";
RL   J. Gen. Virol. 82:321-330(2001).
CC   -!- FUNCTION: Component of the molecular motor that translocates viral
CC       genomic DNA in empty capsid during DNA packaging. Forms a tripartite
CC       terminase complex together with TRM1 and TRM3 in the host cytoplasm.
CC       Once the complex reaches the host nucleus, it interacts with the capsid
CC       portal vertex. This portal forms a ring in which genomic DNA is
CC       translocated into the capsid. {ECO:0000255|HAMAP-Rule:MF_04015}.
CC   -!- SUBUNIT: Associates with TRM1 and TRM3 to form the tripartite terminase
CC       complex. {ECO:0000255|HAMAP-Rule:MF_04015}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04015,
CC       ECO:0000269|PubMed:11161269}. Note=Found associated with the external
CC       surface of the viral capsid during assembly and DNA packaging, but
CC       seems absent in extracellular mature virions. {ECO:0000255|HAMAP-
CC       Rule:MF_04015}.
CC   -!- SIMILARITY: Belongs to the herpesviridae TRM2 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04015}.
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DR   EMBL; Z86099; CAB06758.1; -; Genomic_DNA.
DR   RefSeq; YP_009137185.1; NC_001798.2.
DR   SMR; P89456; -.
DR   PRIDE; P89456; -.
DR   DNASU; 1487319; -.
DR   GeneID; 1487319; -.
DR   KEGG; vg:1487319; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019073; P:viral DNA genome packaging; IEA:UniProtKB-UniRule.
DR   GO; GO:0019076; P:viral release from host cell; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04015; HSV_TRM2; 1.
DR   InterPro; IPR005208; Herpes_TT2.
DR   Pfam; PF03581; Herpes_UL33; 1.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome; Viral genome packaging;
KW   Viral release from host cell.
FT   CHAIN           1..130
FT                   /note="Tripartite terminase subunit 2"
FT                   /id="PRO_0000406181"
SQ   SEQUENCE   130 AA;  14345 MW;  CBAE8E2F6AE0A1A3 CRC64;
     MAGRAGRTRP RTLRDAIPDC ALRSQTLESL DARYVSRDGA GDAAVWFEDM TPAELEVIFP
     TTDAKLNYLS RTQRLASLLT YAGPIKAPDG PAAPHTQDTA CVHGELLARK RERFAAVINR
     FLDLHQILRG