TRM6_ASHGO
ID TRM6_ASHGO Reviewed; 459 AA.
AC Q75B32;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6;
DE AltName: Full=tRNA(m1A58)-methyltransferase subunit TRM6;
DE Short=tRNA(m1A58)MTase subunit TRM6;
GN Name=TRM6; OrderedLocusNames=ADL255C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Substrate-binding subunit of tRNA (adenine-N(1)-)-
CC methyltransferase, which catalyzes the formation of N(1)-methyladenine
CC at position 58 (m1A58) in initiator methionyl-tRNA.
CC {ECO:0000250|UniProtKB:P41814}.
CC -!- SUBUNIT: Heterotetramer; composed of two copies of TRM6 and two copies
CC of TRM61. {ECO:0000250|UniProtKB:P41814}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P41814}.
CC -!- SIMILARITY: Belongs to the TRM6/GCD10 family. {ECO:0000305}.
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DR EMBL; AE016817; AAS51665.1; -; Genomic_DNA.
DR RefSeq; NP_983841.1; NM_209194.1.
DR AlphaFoldDB; Q75B32; -.
DR SMR; Q75B32; -.
DR STRING; 33169.AAS51665; -.
DR EnsemblFungi; AAS51665; AAS51665; AGOS_ADL255C.
DR GeneID; 4619976; -.
DR KEGG; ago:AGOS_ADL255C; -.
DR eggNOG; KOG1416; Eukaryota.
DR HOGENOM; CLU_010916_1_1_1; -.
DR InParanoid; Q75B32; -.
DR OMA; TFHNRTE; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031515; C:tRNA (m1A) methyltransferase complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016429; F:tRNA (adenine-N1-)-methyltransferase activity; IEA:EnsemblFungi.
DR InterPro; IPR017423; TRM6.
DR PANTHER; PTHR12945; PTHR12945; 1.
DR Pfam; PF04189; Gcd10p; 1.
DR PIRSF; PIRSF038170; tRNA_m1A_mtfrase; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; RNA-binding; tRNA processing.
FT CHAIN 1..459
FT /note="tRNA (adenine(58)-N(1))-methyltransferase non-
FT catalytic subunit TRM6"
FT /id="PRO_0000256157"
SQ SEQUENCE 459 AA; 51413 MW; E29D3D9CE9EE65D9 CRC64;
MDPLRQLVLN QHILVRLPSD NLKIVELKPN GVISLGKFGA CHVNDIIGYP LGTTFEIWYE
GDETEVVRGS TVVIGKVRVL ENRAEAQVGS EGATPQPAEL TQVESSKTNM ELLDLGHKVQ
KLDHKEIERM KQDVTAGDSI ISMMIQSHET FHKKTIHSQE KYLKRKKQKF AKFFTAEYLG
SSGLLRYLIE KGDMQRIMDL SEESLGMALN LANIRSNGTY LCMDETGGLI VYAMLERMFG
GHEAQHGGTI VVVHENEHPN LDLLKFSNYS EEFIGKHVKT VSLLQYFEPP TVEEVEASFT
PLDDAQLREM KSNKKGAYYR RLKRYNSDLE VIRLASQITY DALIVASTLQ LSTLVPRLAG
KVHGSRPIVC YSQFRETLLE LSHTLYDSLH FLAPTLLETR CRPYQTVRGK LHPLMTMRGG
GGYLLWCHKV IPADNGAGKI DCDNAAAPAC PAAQPDEAP
