ID   TRM6_ASPFU              Reviewed;         572 AA.
AC   Q4WE58;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit trm6;
DE   AltName: Full=tRNA(m1A58)-methyltransferase subunit trm6;
DE            Short=tRNA(m1A58)MTase subunit trm6;
GN   Name=trm6; ORFNames=AFUA_5G01850;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Substrate-binding subunit of tRNA (adenine-N(1)-)-
CC       methyltransferase, which catalyzes the formation of N(1)-methyladenine
CC       at position 58 (m1A58) in initiator methionyl-tRNA.
CC       {ECO:0000250|UniProtKB:P41814}.
CC   -!- SUBUNIT: Heterotetramer; composed of two copies of TRM6 and two copies
CC       of TRM61. {ECO:0000250|UniProtKB:P41814}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P41814}.
CC   -!- SIMILARITY: Belongs to the TRM6/GCD10 family. {ECO:0000305}.
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DR   EMBL; AAHF01000011; EAL86119.1; -; Genomic_DNA.
DR   RefSeq; XP_748157.1; XM_743064.1.
DR   AlphaFoldDB; Q4WE58; -.
DR   STRING; 746128.CADAFUBP00004929; -.
DR   EnsemblFungi; EAL86119; EAL86119; AFUA_5G01850.
DR   GeneID; 3505377; -.
DR   KEGG; afm:AFUA_5G01850; -.
DR   VEuPathDB; FungiDB:Afu5g01850; -.
DR   eggNOG; KOG1416; Eukaryota.
DR   HOGENOM; CLU_010916_2_0_1; -.
DR   InParanoid; Q4WE58; -.
DR   OMA; PFYLTFE; -.
DR   OrthoDB; 543764at2759; -.
DR   Proteomes; UP000002530; Chromosome 5.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0031515; C:tRNA (m1A) methyltransferase complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030488; P:tRNA methylation; IEA:InterPro.
DR   InterPro; IPR017423; TRM6.
DR   PANTHER; PTHR12945; PTHR12945; 1.
DR   Pfam; PF04189; Gcd10p; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; RNA-binding; tRNA processing.
FT   CHAIN           1..572
FT                   /note="tRNA (adenine(58)-N(1))-methyltransferase non-
FT                   catalytic subunit trm6"
FT                   /id="PRO_0000256158"
FT   REGION          456..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          538..572
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        555..572
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   572 AA;  63725 MW;  DA46403B3AD10209 CRC64;
     MHSYIRPYQH VALRLPSELT KIVRLVPNTV VYLGKYGSFP ANTIIGRPFY LTFEIIDVSG
     ENNDNCLRIV PPAELHAETL IADGEGEGDD VEVNEEGIPI RTNREIVDDA STQKMTAEEI
     EALKKVSTGA GREIIEKLLE SHSALDQKTA FSLAKYTLRK RKKFLKRFTV LPVDVSLLTN
     YMLEGKEAMK TMELRDESIG LIGCWGNVHH GGQSSFEGAV ASKPNGRYLV IDETGGLVVA
     AMAERMGILY PHDQEDEDQE LAEGSEENGE RQQTNAMAQA LARRRHMAAS GNSITVIHAN
     KQPSLSLLRY FGYDQDNPDE SHPLYKHMKT VSWMQLLDPH ADTIYANEPE VIPDETLATF
     KSNRRSAYYK KRSRWERVRR VVDEARAGNF DGLIVATLME PASVLKHTVP LLAGSAPVVV
     YSPTVEPLTE LADLYSTPRR TAYITRKREI IAQHSLQQSL QGQSQDNEKK PQEPDFSELD
     KDFALDPSLL LAPTIETSRV RAWQVLPGRT HPLMSGRGGA EGYIFHAIRV FPSHQNIQAA
     GNPSRKKRKV AAQQESATPA ESGSGVDVEM QS