ID   TRM6_CANAL              Reviewed;         453 AA.
AC   Q5A6Q4; A0A1D8PSN7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6;
DE   AltName: Full=tRNA(m1A58)-methyltransferase subunit TRM6;
DE            Short=tRNA(m1A58)MTase subunit TRM6;
GN   Name=TRM6; OrderedLocusNames=CAALFM_CR04160CA;
GN   ORFNames=CaO19.500, CaO19.8130;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Substrate-binding subunit of tRNA (adenine-N(1)-)-
CC       methyltransferase, which catalyzes the formation of N(1)-methyladenine
CC       at position 58 (m1A58) in initiator methionyl-tRNA.
CC       {ECO:0000250|UniProtKB:P41814}.
CC   -!- SUBUNIT: Heterotetramer; composed of two copies of TRM6 and two copies
CC       of TRM61. {ECO:0000250|UniProtKB:P41814}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P41814}.
CC   -!- SIMILARITY: Belongs to the TRM6/GCD10 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31154.1; -; Genomic_DNA.
DR   RefSeq; XP_717363.1; XM_712270.1.
DR   AlphaFoldDB; Q5A6Q4; -.
DR   SMR; Q5A6Q4; -.
DR   STRING; 237561.Q5A6Q4; -.
DR   PRIDE; Q5A6Q4; -.
DR   GeneID; 3640976; -.
DR   KEGG; cal:CAALFM_CR04160CA; -.
DR   CGD; CAL0000185106; orf19.8130.
DR   VEuPathDB; FungiDB:CR_04160C_A; -.
DR   eggNOG; KOG1416; Eukaryota.
DR   HOGENOM; CLU_010916_1_1_1; -.
DR   InParanoid; Q5A6Q4; -.
DR   OMA; TFHNRTE; -.
DR   OrthoDB; 543764at2759; -.
DR   PRO; PR:Q5A6Q4; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0031515; C:tRNA (m1A) methyltransferase complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030488; P:tRNA methylation; IEA:InterPro.
DR   InterPro; IPR017423; TRM6.
DR   PANTHER; PTHR12945; PTHR12945; 1.
DR   Pfam; PF04189; Gcd10p; 1.
DR   PIRSF; PIRSF038170; tRNA_m1A_mtfrase; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; RNA-binding; tRNA processing.
FT   CHAIN           1..453
FT                   /note="tRNA (adenine(58)-N(1))-methyltransferase non-
FT                   catalytic subunit TRM6"
FT                   /id="PRO_0000256160"
FT   REGION          430..453
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..453
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  51182 MW;  6D64ACE1C01076AB CRC64;
     MSDFKKSETT IQSGQHVLIR LPSEGLKIVH LQDTGIIGLG KFGSFEVSNI LGYPLGTSFE
     IIEDHKVKPI KSISTLDLTD SDETVQRQEL TKMFSDSAEN NQNIINIGSK IQKLSKDDID
     ELKKSGASSN VGQMIIEKMI AGHEGFDKKT IFSQQKYLKR KQQKFLRRFT VDYLGGSELL
     QYYIEKDLNR VLDLSVETLG LMLTYSNVRP GGKYLIIDET GGVLTYAMME RMNCEGTIVS
     IHENEHANLI ALRYSDYGNE LETKTVKSVN WLQFIDPQSE RIDWTDLPDE EVKKIKNKSQ
     YKKRRDRALQ INEVIQLVEE GNFDAFISVS TLNMSEVLEY VLPKIGGSRP IVVYNQFKES
     LLEVQQALSG DKRVLAPSIY ETRVRPYQTI PGRMHPVMTN RGGGGYILWG TRVIPHDAIT
     AVGKGFAKRK RVETPSKTDT GTVEVQNDQE NSA