ID   TRM6_CANGA              Reviewed;         473 AA.
AC   Q6FNP9;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6;
DE   AltName: Full=tRNA(m1A58)-methyltransferase subunit TRM6;
DE            Short=tRNA(m1A58)MTase subunit TRM6;
GN   Name=TRM6; OrderedLocusNames=CAGL0J10010g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Substrate-binding subunit of tRNA (adenine-N(1)-)-
CC       methyltransferase, which catalyzes the formation of N(1)-methyladenine
CC       at position 58 (m1A58) in initiator methionyl-tRNA.
CC       {ECO:0000250|UniProtKB:P41814}.
CC   -!- SUBUNIT: Heterotetramer; composed of two copies of TRM6 and two copies
CC       of TRM61. {ECO:0000250|UniProtKB:P41814}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P41814}.
CC   -!- SIMILARITY: Belongs to the TRM6/GCD10 family. {ECO:0000305}.
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DR   EMBL; CR380956; CAG61096.1; -; Genomic_DNA.
DR   RefSeq; XP_448145.1; XM_448145.1.
DR   AlphaFoldDB; Q6FNP9; -.
DR   SMR; Q6FNP9; -.
DR   STRING; 5478.XP_448145.1; -.
DR   EnsemblFungi; CAG61096; CAG61096; CAGL0J10010g.
DR   GeneID; 2889430; -.
DR   KEGG; cgr:CAGL0J10010g; -.
DR   CGD; CAL0133494; CAGL0J10010g.
DR   VEuPathDB; FungiDB:CAGL0J10010g; -.
DR   eggNOG; KOG1416; Eukaryota.
DR   HOGENOM; CLU_010916_1_1_1; -.
DR   InParanoid; Q6FNP9; -.
DR   OMA; TFHNRTE; -.
DR   Proteomes; UP000002428; Chromosome J.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031515; C:tRNA (m1A) methyltransferase complex; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016429; F:tRNA (adenine-N1-)-methyltransferase activity; IEA:EnsemblFungi.
DR   InterPro; IPR017423; TRM6.
DR   PANTHER; PTHR12945; PTHR12945; 1.
DR   Pfam; PF04189; Gcd10p; 1.
DR   PIRSF; PIRSF038170; tRNA_m1A_mtfrase; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; RNA-binding; tRNA processing.
FT   CHAIN           1..473
FT                   /note="tRNA (adenine(58)-N(1))-methyltransferase non-
FT                   catalytic subunit TRM6"
FT                   /id="PRO_0000256161"
FT   REGION          452..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   473 AA;  53962 MW;  1C5E62CC3C4DB958 CRC64;
     MDPLKSIVQD QHVILTLPSG NSKIVELKPD SSVSLGKFGA FQVNDILGWP LGTTFEIYYD
     NVEEIVENKK KKPKSNELNK VPVGKVRLYK EVATDDKAEE EVEEMDSSAV IPVELQNVLS
     SATNQGLINI GNDVQKLTMH DVERFKQQSA SANEIITKMI ESHGSFHQKT IYSQEKYLKR
     KKQKFAKFFT VDYLSSSMLL KFLVEKGDIQ RVLDLSEESL GMILNLTNIR SDGTYLCMDE
     TGGLIVYTML ERMFGGKEDL DAPGKIVVIN ENEHPNLDLL KFSNYSEKFI EKHVVTLSIL
     DYFRPPTMEE VEGRFTPLSK EEVNKLKSGK RSAYSRKLKW YYTQLRVIEM ATKQQYDGLV
     VASTLHLPSL VPRLAERVHG ARPIVCFSQF KETLLELAHT LYSDLRYLAP TILETRCRPY
     QTARGKLHPL MTMRGGGGYL LWCHRVIPAP EPEIEEPTDV NADEQEEKKQ KME