ID   TRM6_DEBHA              Reviewed;         473 AA.
AC   Q6BKK7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6;
DE   AltName: Full=tRNA(m1A58)-methyltransferase subunit TRM6;
DE            Short=tRNA(m1A58)MTase subunit TRM6;
GN   Name=TRM6; OrderedLocusNames=DEHA2F21032g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Substrate-binding subunit of tRNA (adenine-N(1)-)-
CC       methyltransferase, which catalyzes the formation of N(1)-methyladenine
CC       at position 58 (m1A58) in initiator methionyl-tRNA.
CC       {ECO:0000250|UniProtKB:P41814}.
CC   -!- SUBUNIT: Heterotetramer; composed of two copies of TRM6 and two copies
CC       of TRM61. {ECO:0000250|UniProtKB:P41814}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P41814}.
CC   -!- SIMILARITY: Belongs to the TRM6/GCD10 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG89653.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR382138; CAG89653.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_461264.2; XM_461264.2.
DR   AlphaFoldDB; Q6BKK7; -.
DR   SMR; Q6BKK7; -.
DR   STRING; 4959.XP_461264.2; -.
DR   EnsemblFungi; CAG89653; CAG89653; DEHA2F21032g.
DR   GeneID; 2903972; -.
DR   KEGG; dha:DEHA2F21032g; -.
DR   eggNOG; KOG1416; Eukaryota.
DR   HOGENOM; CLU_010916_2_0_1; -.
DR   InParanoid; Q6BKK7; -.
DR   OrthoDB; 543764at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031515; C:tRNA (m1A) methyltransferase complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030488; P:tRNA methylation; IEA:InterPro.
DR   InterPro; IPR017423; TRM6.
DR   PANTHER; PTHR12945; PTHR12945; 1.
DR   Pfam; PF04189; Gcd10p; 1.
DR   PIRSF; PIRSF038170; tRNA_m1A_mtfrase; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; RNA-binding; tRNA processing.
FT   CHAIN           1..473
FT                   /note="tRNA (adenine(58)-N(1))-methyltransferase non-
FT                   catalytic subunit TRM6"
FT                   /id="PRO_0000256163"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          445..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   473 AA;  53611 MW;  7FF03E3E9D15CB12 CRC64;
     MASVIEDKMN LDREPEVDSL PQREKSTTII SPNQHALIRL PSEGLKIIDL KPGGIISLGK
     FGTFAVDGIL GYPFGQTFEI LEELKVKPIK SMTMQADETS VDNENEELTK DDLTKMLSNS
     SDNNQNIINI GSKIQKLTSE DVDKLKESGA TSDIGQRIIE QMIAGHEGFD KKTLFSQQKY
     LKRKQQKFLR RFTVEYLGSS QLLQYYIEKD TQRVLDMSEE TLGLLLNYAN VRPGGKYLLI
     DETGGIILYA MMERMNGQGT IVSAHDNEHP NHIALRYSDY PEEMQNRMVK SINWLQFLEP
     ENEKVEFETA TEEEIEEMKH AKRAQYYRRE QRAKNINSVI DMVMEGNFDG FISVSTLNMP
     TLLPEIIPTI GGSRPVVIYS QFKEALLETQ HHMSTDKRVL APSIMETRVR PHQTIPGRMH
     PVMCMRGFGG YILWGTRVFP RESGITAVGK GSGKSKKEKP EQIPEAVSQQ ASV