ID   TRM6_KLULA              Reviewed;         476 AA.
AC   Q6CLF6;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6;
DE   AltName: Full=tRNA(m1A58)-methyltransferase subunit TRM6;
DE            Short=tRNA(m1A58)MTase subunit TRM6;
GN   Name=TRM6; OrderedLocusNames=KLLA0F03377g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Substrate-binding subunit of tRNA (adenine-N(1)-)-
CC       methyltransferase, which catalyzes the formation of N(1)-methyladenine
CC       at position 58 (m1A58) in initiator methionyl-tRNA.
CC       {ECO:0000250|UniProtKB:P41814}.
CC   -!- SUBUNIT: Heterotetramer; composed of two copies of TRM6 and two copies
CC       of TRM61. {ECO:0000250|UniProtKB:P41814}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P41814}.
CC   -!- SIMILARITY: Belongs to the TRM6/GCD10 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG97941.1; -; Genomic_DNA.
DR   RefSeq; XP_455233.1; XM_455233.1.
DR   AlphaFoldDB; Q6CLF6; -.
DR   SMR; Q6CLF6; -.
DR   STRING; 28985.XP_455233.1; -.
DR   EnsemblFungi; CAG97941; CAG97941; KLLA0_F03377g.
DR   GeneID; 2895721; -.
DR   KEGG; kla:KLLA0_F03377g; -.
DR   eggNOG; KOG1416; Eukaryota.
DR   HOGENOM; CLU_010916_2_0_1; -.
DR   InParanoid; Q6CLF6; -.
DR   OMA; TFHNRTE; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031515; C:tRNA (m1A) methyltransferase complex; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016429; F:tRNA (adenine-N1-)-methyltransferase activity; IEA:EnsemblFungi.
DR   InterPro; IPR017423; TRM6.
DR   PANTHER; PTHR12945; PTHR12945; 1.
DR   Pfam; PF04189; Gcd10p; 1.
DR   PIRSF; PIRSF038170; tRNA_m1A_mtfrase; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; RNA-binding; tRNA processing.
FT   CHAIN           1..476
FT                   /note="tRNA (adenine(58)-N(1))-methyltransferase non-
FT                   catalytic subunit TRM6"
FT                   /id="PRO_0000256164"
FT   REGION          433..476
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   476 AA;  53838 MW;  6B0865178C9A9E43 CRC64;
     MTKHSGIDPL TQISPNQHVL IRLPSDNLKI VELKANAIVS LGKFGAFRVN EIIGYRFGTT
     FDIVYDGVEE EFVKGTQTMI GKISVLENRL KASSPALENS SENNRGLINL GSVVQEMSMA
     EIEAMKREAA SGDAIISKMI ESHKSFHQKT VHSQEKYLKR KKQKFAKFFT VEYLDSSGLL
     HYLIEKGDVL RVMDISQESL GMALNLANIN SNGQYLCIDE TGGLIVYAML ERMFAGDSNS
     KANGKIVVVH ENEHPNLDLL KFSSYSDNFI QRHVKTISVL DFFEPAKEAD IKSLFKPLSA
     EEINDLKSNK KSAYFRRLKW YHNQLSNIEV AASSFDGLLV ASTLYLPTLI PRLGEKIHGS
     RPIVCYSQYK EPLLELSHSL YENLNYLAPS LLETRCRPYQ TVRGKLHPLM TMKGGGGYLM
     WCHRVLPAAE PKLHQETLEK SEIKNSDEEG DEDAHKLDQE KQVIKRRKPN EDNEKL