TRM6_SCHPO
ID TRM6_SCHPO Reviewed; 462 AA.
AC Q9HGL4;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit trm6;
DE AltName: Full=General control non-derepressible protein 10;
DE Short=Protein gcd10;
DE AltName: Full=tRNA(m1A58)-methyltransferase subunit trm6;
DE Short=tRNA(m1A58)MTase subunit trm6;
GN Name=gcd10; Synonyms=trm6; ORFNames=SPBC800.08;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Substrate-binding subunit of tRNA (adenine-N(1)-)-
CC methyltransferase, which catalyzes the formation of N(1)-methyladenine
CC at position 58 (m1A58) in initiator methionyl-tRNA.
CC {ECO:0000250|UniProtKB:P41814}.
CC -!- SUBUNIT: Heterotetramer; composed of two copies of TRM6 and two copies
CC of TRM61. {ECO:0000250|UniProtKB:P41814}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the TRM6/GCD10 family. {ECO:0000305}.
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DR EMBL; CU329671; CAC01523.1; -; Genomic_DNA.
DR RefSeq; NP_595109.1; NM_001021016.2.
DR AlphaFoldDB; Q9HGL4; -.
DR SMR; Q9HGL4; -.
DR BioGRID; 277223; 52.
DR STRING; 4896.SPBC800.08.1; -.
DR iPTMnet; Q9HGL4; -.
DR MaxQB; Q9HGL4; -.
DR PaxDb; Q9HGL4; -.
DR PRIDE; Q9HGL4; -.
DR EnsemblFungi; SPBC800.08.1; SPBC800.08.1:pep; SPBC800.08.
DR GeneID; 2540699; -.
DR KEGG; spo:SPBC800.08; -.
DR PomBase; SPBC800.08; gcd10.
DR VEuPathDB; FungiDB:SPBC800.08; -.
DR eggNOG; KOG1416; Eukaryota.
DR HOGENOM; CLU_010916_0_3_1; -.
DR InParanoid; Q9HGL4; -.
DR OMA; TFHNRTE; -.
DR PhylomeDB; Q9HGL4; -.
DR PRO; PR:Q9HGL4; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0031515; C:tRNA (m1A) methyltransferase complex; ISO:PomBase.
DR GO; GO:0000049; F:tRNA binding; ISO:PomBase.
DR GO; GO:0030488; P:tRNA methylation; ISO:PomBase.
DR InterPro; IPR017423; TRM6.
DR PANTHER; PTHR12945; PTHR12945; 1.
DR Pfam; PF04189; Gcd10p; 1.
DR PIRSF; PIRSF038170; tRNA_m1A_mtfrase; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; RNA-binding; tRNA processing.
FT CHAIN 1..462
FT /note="tRNA (adenine(58)-N(1))-methyltransferase non-
FT catalytic subunit trm6"
FT /id="PRO_0000256165"
FT REGION 442..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 53201 MW; BABFC709B2634ACE CRC64;
MLRHASTISE NSSVFIKLPS DNVRFVTLKP NNTIHLGKFG SFLADDLFGK HFDETFEIYQ
PKKIRVLKTR EVQYIEEEKK TNQELNDCRG NQLMTQEEID ELRANIKAGG LRAEEAIKQL
TNSSKTFEQK TLFAQEKYVT RKGEKYLQRF QVLRPCVEVV ANYMIEHDPY KILDLTAECI
SLMLTLGNVK PGGRYLVVDE TGCMFLGSLI DRVAGDCKIT LVHPNEQPNS SCLEYWGQDF
KEDSLVQKGI LKTLNWYQVT NPTETLSEYS VEDIPESELN EMKLRHRKRY ETKKATFNRL
KNTIDDFESG NYDALFILSI HTPMSVLQHL LPKLGISRPF MVYSTYQQVL VETYHQLSKW
DNLFVEKTAQ STENDEKVDQ GDVAIDTQKE KVIMLDIHEI RTRPYQVLPE RTHPFMTVRG
DMGFVLSGIK VLTSDSNLAA GRFPKRKGQK ETSSVKKAKL EN
