TRM82_CANAL
ID TRM82_CANAL Reviewed; 426 AA.
AC Q5AH60; A0A1D8PR35; Q3MPB0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 3.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82 {ECO:0000255|HAMAP-Rule:MF_03056};
DE AltName: Full=Transfer RNA methyltransferase 82 {ECO:0000255|HAMAP-Rule:MF_03056};
GN Name=TRM82 {ECO:0000255|HAMAP-Rule:MF_03056};
GN OrderedLocusNames=CAALFM_C702340CA;
GN ORFNames=CaJ7.0274, CaO19.13831, CaO19.6477;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15937140; DOI=10.1534/genetics.104.034652;
RA Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T.,
RA Mikami Y.;
RT "Sequence finishing and gene mapping for Candida albicans chromosome 7 and
RT syntenic analysis against the Saccharomyces cerevisiae genome.";
RL Genetics 170:1525-1537(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Required for the formation of N(7)-methylguanine at position
CC 46 (m7G46) in tRNA. In the complex, it is required to stabilize and
CC induce conformational changes of the catalytic subunit.
CC {ECO:0000255|HAMAP-Rule:MF_03056}.
CC -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_03056}.
CC -!- SUBUNIT: Forms a heterodimer with the catalytic subunit TRM8.
CC {ECO:0000255|HAMAP-Rule:MF_03056}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03056}.
CC -!- SIMILARITY: Belongs to the WD repeat TRM82 family. {ECO:0000255|HAMAP-
CC Rule:MF_03056}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE44750.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AP006852; BAE44750.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP017629; AOW30595.1; -; Genomic_DNA.
DR RefSeq; XP_721318.2; XM_716225.2.
DR AlphaFoldDB; Q5AH60; -.
DR SMR; Q5AH60; -.
DR STRING; 237561.Q5AH60; -.
DR PRIDE; Q5AH60; -.
DR GeneID; 3636933; -.
DR KEGG; cal:CAALFM_C702340CA; -.
DR CGD; CAL0000187643; orf19.13831.
DR VEuPathDB; FungiDB:C7_02340C_A; -.
DR eggNOG; KOG3914; Eukaryota.
DR HOGENOM; CLU_022082_0_0_1; -.
DR InParanoid; Q5AH60; -.
DR OrthoDB; 937275at2759; -.
DR UniPathway; UPA00989; -.
DR Proteomes; UP000000559; Chromosome 7.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0106143; C:tRNA (m7G46) methyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0043527; C:tRNA methyltransferase complex; IBA:GO_Central.
DR GO; GO:0008176; F:tRNA (guanine-N7-)-methyltransferase activity; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 2.
DR HAMAP; MF_03056; TRM82; 1.
DR InterPro; IPR028884; Trm82.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR16288; PTHR16288; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; tRNA processing; WD repeat.
FT CHAIN 1..426
FT /note="tRNA (guanine-N(7)-)-methyltransferase non-catalytic
FT subunit TRM82"
FT /id="PRO_0000370516"
FT REPEAT 69..111
FT /note="WD 1"
FT REPEAT 170..225
FT /note="WD 2"
FT REPEAT 227..270
FT /note="WD 3"
FT CONFLICT 311
FT /note="E -> D (in Ref. 1; BAE44750)"
FT /evidence="ECO:0000305"
FT CONFLICT 345
FT /note="A -> T (in Ref. 1; BAE44750)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 49087 MW; 46A6E513ABA8B920 CRC64;
MKHPFQILIT NKKGTHIFAI VKNYLQVFDI SKGGGDDDIK VGEWQDTTES NHPKIQIEKR
TGRQISTQQI HNHLRYLILT PDEQHIIAST DSDKSILIFK IDFNNSINCL KLIKRQPIPK
RPSSITIDSQ GQRAIVADKF GDVYTVSIND DSSMSEIEIE IEKDIQPILG HVSMLTDITM
ATTHHNNNNN NNNNNNNKQF IITADRDEHI RISNYPKSYV IKNFLFGHDE FVSQLYIPVQ
YDPSILISGG GDDFINIWKW YEGELIETIQ LRQYIESYLS DDHLPPTRFR TETSPKEISI
AKIATLRTND EEEEEDHLLI VLVENTPVLL VFNLDDSYKA KYLQAIIVND SIIDFAIAAD
NKTIITSLES EQHSIKYFTL QEENDGKKFS EIQGPNIEQF IPIEVEQKSD FQQLYTIFQL
RKRSDS
