ID   TRM82_CANGA             Reviewed;         421 AA.
AC   Q6FVL4;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82 {ECO:0000255|HAMAP-Rule:MF_03056};
DE   AltName: Full=Transfer RNA methyltransferase 82 {ECO:0000255|HAMAP-Rule:MF_03056};
GN   Name=TRM82 {ECO:0000255|HAMAP-Rule:MF_03056};
GN   OrderedLocusNames=CAGL0E00979g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the formation of N(7)-methylguanine at position
CC       46 (m7G46) in tRNA. In the complex, it is required to stabilize and
CC       induce conformational changes of the catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SUBUNIT: Forms a heterodimer with the catalytic subunit TRM8.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SIMILARITY: Belongs to the WD repeat TRM82 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03056}.
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DR   EMBL; CR380951; CAG58649.1; -; Genomic_DNA.
DR   RefSeq; XP_445730.1; XM_445730.1.
DR   AlphaFoldDB; Q6FVL4; -.
DR   SMR; Q6FVL4; -.
DR   STRING; 5478.XP_445730.1; -.
DR   EnsemblFungi; CAG58649; CAG58649; CAGL0E00979g.
DR   GeneID; 2887360; -.
DR   KEGG; cgr:CAGL0E00979g; -.
DR   CGD; CAL0128862; CAGL0E00979g.
DR   VEuPathDB; FungiDB:CAGL0E00979g; -.
DR   eggNOG; KOG3914; Eukaryota.
DR   HOGENOM; CLU_022082_0_0_1; -.
DR   InParanoid; Q6FVL4; -.
DR   OMA; PPIYNYI; -.
DR   UniPathway; UPA00989; -.
DR   Proteomes; UP000002428; Chromosome E.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0106143; C:tRNA (m7G46) methyltransferase complex; IEA:EnsemblFungi.
DR   GO; GO:0008176; F:tRNA (guanine-N7-)-methyltransferase activity; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03056; TRM82; 1.
DR   InterPro; IPR028884; Trm82.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR16288; PTHR16288; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; tRNA processing; WD repeat.
FT   CHAIN           1..421
FT                   /note="tRNA (guanine-N(7)-)-methyltransferase non-catalytic
FT                   subunit TRM82"
FT                   /id="PRO_0000370517"
FT   REPEAT          72..112
FT                   /note="WD 1"
FT   REPEAT          170..212
FT                   /note="WD 2"
FT   REPEAT          216..258
FT                   /note="WD 3"
SQ   SEQUENCE   421 AA;  47568 MW;  892A54E5EB1E9E77 CRC64;
     MFVHPLNVAI SDSQNKYQYV VCKHTISVFA GEKLVGYWVD TDQRDSHNSY KKLKSNAGDA
     KPKGSQGIGA PAVYSYIRNL RLTSDEGKLI ACVDSDKSVV IFKIDTSAED PEKFLQVMKR
     QQFPKRPNAL ALADEDTTII VADKFGDVYK LKIDEEPIRK IDDQSEPILG HVSMLTDVAV
     AKDANNKSYI ITTDRDEHIK ISHYPQTFIV DKWLFGHKEF VSSVDLPKWQ TKFLFSAGGD
     KEIFAWNWQS GELLSQYSFE DAVKPFINDQ HLAPARFQNE ENNVIEYAVA SIKSCGQQPY
     VAFFVEATPV LFILHCNTET GELSLAQQVE FKHNVVSISS NGKSEYLVTF DNRDENAEQL
     IAFLTYSGDS NKPFSVDENL NKLNSSWIST FKQKDELLAD ADSVYPLYNI ASLKKHGEHF
     S