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TRM82_CRYNJ
ID   TRM82_CRYNJ             Reviewed;         569 AA.
AC   P0CS52; Q55PH3; Q5KDY5;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82 {ECO:0000255|HAMAP-Rule:MF_03056};
DE   AltName: Full=Transfer RNA methyltransferase 82 {ECO:0000255|HAMAP-Rule:MF_03056};
GN   Name=TRM82 {ECO:0000255|HAMAP-Rule:MF_03056}; OrderedLocusNames=CNG02370;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Required for the formation of N(7)-methylguanine at position
CC       46 (m7G46) in tRNA. In the complex, it is required to stabilize and
CC       induce conformational changes of the catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SUBUNIT: Forms a heterodimer with the catalytic subunit TRM8.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SIMILARITY: Belongs to the WD repeat TRM82 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03056}.
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DR   EMBL; AE017347; AAW44655.1; -; Genomic_DNA.
DR   RefSeq; XP_571962.1; XM_571962.1.
DR   AlphaFoldDB; P0CS52; -.
DR   SMR; P0CS52; -.
DR   STRING; 5207.AAW44655; -.
DR   PaxDb; P0CS52; -.
DR   EnsemblFungi; AAW44655; AAW44655; CNG02370.
DR   GeneID; 3258810; -.
DR   KEGG; cne:CNG02370; -.
DR   VEuPathDB; FungiDB:CNG02370; -.
DR   eggNOG; KOG3914; Eukaryota.
DR   HOGENOM; CLU_023695_0_0_1; -.
DR   InParanoid; P0CS52; -.
DR   OMA; THATVNT; -.
DR   OrthoDB; 937275at2759; -.
DR   UniPathway; UPA00989; -.
DR   Proteomes; UP000002149; Chromosome 7.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0043527; C:tRNA methyltransferase complex; IBA:GO_Central.
DR   GO; GO:0106004; P:tRNA (guanine-N7)-methylation; IEA:GOC.
DR   Gene3D; 2.130.10.10; -; 2.
DR   HAMAP; MF_03056; TRM82; 1.
DR   InterPro; IPR028884; Trm82.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR16288; PTHR16288; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; tRNA processing; WD repeat.
FT   CHAIN           1..569
FT                   /note="tRNA (guanine-N(7)-)-methyltransferase non-catalytic
FT                   subunit TRM82"
FT                   /id="PRO_0000370519"
FT   REPEAT          42..81
FT                   /note="WD 1"
FT   REPEAT          147..188
FT                   /note="WD 2"
FT   REPEAT          190..230
FT                   /note="WD 3"
FT   REGION          522..569
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   569 AA;  61680 MW;  C4A371A324D5FCB6 CRC64;
     MALHCPPTAL ATSSTSLFIA AGPALHVFNP STSTFASCAA DGTGGLIRLL AVREDGEVAA
     TLGEDKQLAV WDIQHDRPQF RHTRTVVKKG SCLSFAKDGS IILTDKVGDV YSYPLDPVPI
     DPSAERPPMY TLVADPSQNP DATYLLGHVS MLNAHVMTPD GRRIITADRD EHIRVSRYPK
     AYVIDKYLFG HDGFVSALHI PPSNPSLLLS AGGDPSLLIW NPSTGKLLTS VPVWPAVLSH
     RRVRSHLRRH KPGSRKLKMD PVPEDMDEEN QTFYTAPEGY MLPSGQGVCI KKIESVKIGG
     ETVVLFFSEG ASAIHSFILP TDPEGVKPTV HTLPLPHPLI DFTPIPSTSS ADEKEVLLSL
     DTAWDVLKKN PGPGIEGRQD TIQRDDLSDE EKRNISKIFS VARISADGHL SLGDASVYDS
     LVSNLPSTDI KTLSNVNLYP LLCVLPRWPG FEEGDEELTV NTGTPDTPGT PGPADAVSLA
     PTSGAFLQKS YTQEELEKMN TKQLGRLKSA GIDVGSILLA RQKKAKEEHK ARKAAAKAKA
     EAQKNQKEGG RPAKKKKKVE MSEEELANA
 
 
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