ID   TRM82_YARLI             Reviewed;         383 AA.
AC   Q6C705;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82 {ECO:0000255|HAMAP-Rule:MF_03056};
DE   AltName: Full=Transfer RNA methyltransferase 82 {ECO:0000255|HAMAP-Rule:MF_03056};
GN   Name=TRM82 {ECO:0000255|HAMAP-Rule:MF_03056};
GN   OrderedLocusNames=YALI0E04785g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the formation of N(7)-methylguanine at position
CC       46 (m7G46) in tRNA. In the complex, it is required to stabilize and
CC       induce conformational changes of the catalytic subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SUBUNIT: Forms a heterodimer with the catalytic subunit TRM8.
CC       {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03056}.
CC   -!- SIMILARITY: Belongs to the WD repeat TRM82 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03056}.
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DR   EMBL; CR382131; CAG79138.1; -; Genomic_DNA.
DR   RefSeq; XP_503557.1; XM_503557.1.
DR   AlphaFoldDB; Q6C705; -.
DR   SMR; Q6C705; -.
DR   STRING; 4952.CAG79138; -.
DR   EnsemblFungi; CAG79138; CAG79138; YALI0_E04785g.
DR   GeneID; 2912213; -.
DR   KEGG; yli:YALI0E04785g; -.
DR   VEuPathDB; FungiDB:YALI0_E04785g; -.
DR   HOGENOM; CLU_022082_0_0_1; -.
DR   InParanoid; Q6C705; -.
DR   OMA; PPIYNYI; -.
DR   UniPathway; UPA00989; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0043527; C:tRNA methyltransferase complex; IBA:GO_Central.
DR   GO; GO:0106004; P:tRNA (guanine-N7)-methylation; IEA:GOC.
DR   Gene3D; 2.130.10.10; -; 2.
DR   HAMAP; MF_03056; TRM82; 1.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR028884; Trm82.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   PANTHER; PTHR16288; PTHR16288; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; tRNA processing; WD repeat.
FT   CHAIN           1..383
FT                   /note="tRNA (guanine-N(7)-)-methyltransferase non-catalytic
FT                   subunit TRM82"
FT                   /id="PRO_0000370528"
FT   REPEAT          66..105
FT                   /note="WD 1"
FT   REPEAT          156..200
FT                   /note="WD 2"
FT   REPEAT          202..244
FT                   /note="WD 3"
SQ   SEQUENCE   383 AA;  42321 MW;  0A5359A0D575C6E7 CRC64;
     MKHPYHIVSL SPDGKTMYAA AARQVDRICL ETGECKSTVV EESATRTTTK TGDKPAAAKR
     TKYLPTSVSH VRSLQLSKGG KYLLATTDET KSLVLLDPTT LEVIKKVQYP KRPSAVATDK
     EDLNIVLGDK FGDVYGESVE DLLKVEGELK DEPVLGHVSM LTALELGYDS KDRPYVISAD
     RDEHIRISRF PASHVIEQFC FGHQQFVSSL LINDLDASIL FSAGGDDEIF VWDWLNGKQL
     QKLSLREHVE SYLNEAHIYV DKKGVATTHK EITVSSLQQI KDTPYLLVNV ESTNAIIVLK
     IVDNKLEVAS VFATEAHVIS FSVAGNLLVT SEVGSEGVKA YTITDGVVTK SDKEIPFGSC
     EYEDDSELIS LFSTKSLRKR GEF