ID   TRM9B_BOVIN             Reviewed;         453 AA.
AC   Q08DH3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Probable tRNA methyltransferase 9B;
DE   AltName: Full=Probable tRNA methyltransferase 9-like protein;
DE            EC=2.1.1.-;
GN   Name=TRMT9B; Synonyms=KIAA1456, TRM9L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May modifie wobble uridines in specific arginine and glutamic
CC       acid tRNAs. Acts as a tumor suppressor by promoting the expression of
CC       LIN9 (By similarity). {ECO:0000250|UniProtKB:Q9P272}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC123749; AAI23750.1; -; mRNA.
DR   RefSeq; NP_001070300.1; NM_001076832.1.
DR   AlphaFoldDB; Q08DH3; -.
DR   SMR; Q08DH3; -.
DR   STRING; 9913.ENSBTAP00000011782; -.
DR   PaxDb; Q08DH3; -.
DR   Ensembl; ENSBTAT00000011782; ENSBTAP00000011782; ENSBTAG00000008950.
DR   Ensembl; ENSBTAT00000081163; ENSBTAP00000058249; ENSBTAG00000008950.
DR   GeneID; 510845; -.
DR   KEGG; bta:510845; -.
DR   CTD; 57604; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008950; -.
DR   eggNOG; KOG1331; Eukaryota.
DR   GeneTree; ENSGT00940000160373; -.
DR   HOGENOM; CLU_029501_0_1_1; -.
DR   OMA; HGNWCIV; -.
DR   OrthoDB; 996085at2759; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000008950; Expressed in oviduct epithelium and 81 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016300; F:tRNA (uracil) methyltransferase activity; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IBA:GO_Central.
DR   Gene3D; 3.40.50.150; -; 2.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR032873; Trm9.
DR   PANTHER; PTHR13069:SF21; PTHR13069:SF21; 1.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   2: Evidence at transcript level;
KW   Methyltransferase; Phosphoprotein; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase; tRNA processing.
FT   CHAIN           1..453
FT                   /note="Probable tRNA methyltransferase 9B"
FT                   /id="PRO_0000328791"
FT   MOD_RES         214
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80WQ4"
SQ   SEQUENCE   453 AA;  50498 MW;  A7F6DD01D92DE965 CRC64;
     MDHAAAQLEK QHVHDVYEST APYFSDLQSK AWPRVRQFLQ EQKPGSLIAD IGCGTGKYLK
     VNSQVHTLGC DYCAPLVEIA RSRGCEVMVC DNLNLPFRDQ GFDAIISIGV IHHFSTKQRR
     IRAIKEMARV LVPGGQLMIY VWAMEQKNRH FEKQDVLVPW NKALCSQRLS ESGQPGRKQE
     CGHPERGYPY HPACSACHCS VCFEGRCNSK RSHSVDCDSV LAGTCCANIS KEGEEENGFY
     NTLGKSFRSW FSSRSLDEST LRKQIEKVRP LKSTESWANS AISIQPSRHS SFDLGHPETL
     SAGEQNLDEE VFVEPSQGPR EWLRAPTTCK QLNGDHPGVI RRNGDGNFLG GANAKESCVD
     EGNLEEGTAS GSKLWRRISA ADSTDSNPGD AISVEEQQPD VLDSRAFMRY YHVFREGELC
     GLLKESVSEL HILSSGNDHG NWCVIAEKRE SCD