ID   BUR2_ASHGO              Reviewed;         401 AA.
AC   Q74ZM2;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 3.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Protein BUR2;
GN   Name=BUR2; OrderedLocusNames=AGR176C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 173; 176-177; 181 AND 203.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the BUR kinase complex involved in transcription
CC       regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin-
CC       conjugating enzyme (E2), leading to monoubiquitination of histone H2B
CC       and the silencing of telomeric-associated genes. Also required for
CC       histone H3 methylation. Necessary for the recovery from pheromone-
CC       induced growth arrest in the cell cycle G1 phase. The kinase activity
CC       of the complex requires the presence of BUR2. Overexpression of BUR2
CC       interferes with mitotic chromosome segregation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the BUR kinase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016820; AAS54666.2; -; Genomic_DNA.
DR   RefSeq; NP_986842.2; NM_211904.2.
DR   AlphaFoldDB; Q74ZM2; -.
DR   SMR; Q74ZM2; -.
DR   STRING; 33169.AAS54666; -.
DR   EnsemblFungi; AAS54666; AAS54666; AGOS_AGR176C.
DR   GeneID; 4623144; -.
DR   KEGG; ago:AGOS_AGR176C; -.
DR   eggNOG; ENOG502QQE8; Eukaryota.
DR   HOGENOM; CLU_698596_0_0_1; -.
DR   InParanoid; Q74ZM2; -.
DR   OMA; LFFRYWY; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0008024; C:cyclin/CDK positive transcription elongation factor complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:EnsemblFungi.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IEA:EnsemblFungi.
DR   GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IBA:GO_Central.
DR   GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; IEA:EnsemblFungi.
DR   GO; GO:0033184; P:positive regulation of histone ubiquitination; IEA:EnsemblFungi.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   SUPFAM; SSF47954; SSF47954; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..401
FT                   /note="Protein BUR2"
FT                   /id="PRO_0000076183"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   401 AA;  46866 MW;  0A2C9C2D6BD42F4C CRC64;
     MAEPDVSDTN TALKKSGEPG MELENNKATS GAVVTEAGFN TRKLWPDLIK LPSNRWVYSC
     KEIVDRLGTD PKAAQLTKKK MEKCLMYFYM IKKNLRLFDH TYTAACILFF RYWYIYELPQ
     SLQDCIHLSQ AILATACKAM ENNRPLDMYV KATCEFMMKD LAQQQRGRQN MDKLKWDVRD
     KLVRYEKQLL CQFGFDLDLQ NPKELIEEIF SGFYRFNRDN IMDEEFKKLF PKILAEARNF
     IIQAGTQPVS LLCDGYTFTA LALLFAGLQY KRSTAPNFRF PRHFFQERFP IRITGPMIVN
     LFTDYRILED NFFDLKSNKG DKLEVTNEEV QSLIDEEPTD ETVPNPYDYE LIKDGVCSQE
     FLDHTESKLK ELTEKIISES LKKRPVIDDN TPKDDTKRVK M