ID   BUR2_CANGA              Reviewed;         357 AA.
AC   Q6FX19;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Protein BUR2;
GN   Name=BUR2; OrderedLocusNames=CAGL0C01177g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the BUR kinase complex involved in transcription
CC       regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin-
CC       conjugating enzyme (E2), leading to monoubiquitination of histone H2B
CC       and the silencing of telomeric-associated genes. Also required for
CC       histone H3 methylation. Necessary for the recovery from pheromone-
CC       induced growth arrest in the cell cycle G1 phase. The kinase activity
CC       of the complex requires the presence of BUR2. Overexpression of BUR2
CC       interferes with mitotic chromosome segregation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the BUR kinase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR380949; CAG58131.1; -; Genomic_DNA.
DR   RefSeq; XP_445225.1; XM_445225.1.
DR   AlphaFoldDB; Q6FX19; -.
DR   SMR; Q6FX19; -.
DR   STRING; 5478.XP_445225.1; -.
DR   EnsemblFungi; CAG58131; CAG58131; CAGL0C01177g.
DR   GeneID; 2886787; -.
DR   KEGG; cgr:CAGL0C01177g; -.
DR   CGD; CAL0127574; CAGL0C01177g.
DR   VEuPathDB; FungiDB:CAGL0C01177g; -.
DR   eggNOG; ENOG502QQE8; Eukaryota.
DR   HOGENOM; CLU_698596_0_0_1; -.
DR   InParanoid; Q6FX19; -.
DR   OMA; LFFRYWY; -.
DR   Proteomes; UP000002428; Chromosome C.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:EnsemblFungi.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:EnsemblFungi.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IEA:EnsemblFungi.
DR   GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; IEA:EnsemblFungi.
DR   GO; GO:0033184; P:positive regulation of histone ubiquitination; IEA:EnsemblFungi.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   SUPFAM; SSF47954; SSF47954; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..357
FT                   /note="Protein BUR2"
FT                   /id="PRO_0000076184"
SQ   SEQUENCE   357 AA;  42596 MW;  4ADF8D54F5828967 CRC64;
     MDEQTGTFNP RVLWPDVIRL PQNRWIFTCK EIIDRLGTDV HKTAEMKKLM EKCLMYLYFM
     KKSLNLFDYT YVEASILFFR YWYYYGLSYN LLDSIHISQA ILVTACKTME NNRPIDAYVK
     STCEFVTIHK IPVGNAGPRP NMDKLKWEFR DRLVKNEKKL LCQFGFDFND GVGNARELIE
     EIFSGFYRFN RDDILPDEFK KTAFPKILQE SRMFIVQGMT QPVTLLCDGY KFVVMSLIYC
     GLEYKRLVDK NFRYPKNFFS RVLLPSLKFN TQELVETFMD YRILEDNFFD LKSNKGSKLH
     ISEEMIRNIT DEDNDFCHSN EELFDYEHIR EGNVSKEFME HIQSKVDAMY EKYKTKV