ID   BUR2_KLULA              Reviewed;         394 AA.
AC   Q6CK68;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Protein BUR2;
GN   Name=BUR2; OrderedLocusNames=KLLA0F13134g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the BUR kinase complex involved in transcription
CC       regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin-
CC       conjugating enzyme (E2), leading to monoubiquitination of histone H2B
CC       and the silencing of telomeric-associated genes. Also required for
CC       histone H3 methylation. Necessary for the recovery from pheromone-
CC       induced growth arrest in the cell cycle G1 phase. The kinase activity
CC       of the complex requires the presence of BUR2. Overexpression of BUR2
CC       interferes with mitotic chromosome segregation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the BUR kinase complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; CR382126; CAG98379.1; -; Genomic_DNA.
DR   RefSeq; XP_455671.1; XM_455671.1.
DR   AlphaFoldDB; Q6CK68; -.
DR   SMR; Q6CK68; -.
DR   STRING; 28985.XP_455671.1; -.
DR   EnsemblFungi; CAG98379; CAG98379; KLLA0_F13134g.
DR   GeneID; 2895964; -.
DR   KEGG; kla:KLLA0_F13134g; -.
DR   eggNOG; ENOG502QQE8; Eukaryota.
DR   HOGENOM; CLU_698596_0_0_1; -.
DR   InParanoid; Q6CK68; -.
DR   OMA; LFFRYWY; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:EnsemblFungi.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:EnsemblFungi.
DR   GO; GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain; IEA:EnsemblFungi.
DR   GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; IEA:EnsemblFungi.
DR   GO; GO:0033184; P:positive regulation of histone ubiquitination; IEA:EnsemblFungi.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   PANTHER; PTHR10026; PTHR10026; 1.
DR   SUPFAM; SSF47954; SSF47954; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..394
FT                   /note="Protein BUR2"
FT                   /id="PRO_0000076185"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          372..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   394 AA;  46015 MW;  8BBA72951F13B97E CRC64;
     MVLSASEEIA NSQPSGNGKT SLDIKQNEGN PQFNPRNLWP DIIKCPKNEW TFEYTDIIKR
     LGTDEEKIQL TKKRMEKCLM YFHKLRKEMK LFDHTYTAAC ILFYRYWYKY DLPPTIPQCI
     HLAQAILVTA CKTMENNRPT DHYIKATCDF MMKDGPSPTG QKLNVEKLKW EVRDQLVSYE
     KKVLCQLGFD LDIDNPKELI EEIFSGYYRH VRDTDIDASL REIFPVILQE ARNFIIQTGT
     QPISLLCDGY TLVALALIFA GVTFQKNKEP GFSFPHNFFR RRFPVIITSE IIASLFSHYQ
     QLEKAFFDLK SNKNSALSIT VDEIDKVIDE DRQLDPEPFN PYDYDIIKEG EVNEELLNYT
     ERKIEELSNR IMSERSIKRP SEPPAEQATK KPRF