BUR6_SCHPO
ID BUR6_SCHPO Reviewed; 199 AA.
AC Q10315; Q9US69;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Transcription regulator complex subunit bur6 {ECO:0000303|PubMed:29109278};
GN Name=bur6 {ECO:0000303|PubMed:29109278}; ORFNames=SPAC17G8.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-172, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [3]
RP FUNCTION, DISRUPTION PHENOTYPE, AND SUBCELLULAR LOCATION.
RX PubMed=15388803; DOI=10.1093/nar/gkh811;
RA Spiga M.-G., D'Urso G.;
RT "Identification and cloning of two putative subunits of DNA polymerase
RT epsilon in fission yeast.";
RL Nucleic Acids Res. 32:4945-4953(2004).
RN [4]
RP FUNCTION.
RX PubMed=29109278; DOI=10.1073/pnas.1712961114;
RA He H., Li Y., Dong Q., Chang A.Y., Gao F., Chi Z., Su M., Zhang F., Ban H.,
RA Martienssen R., Chen Y.H., Li F.;
RT "Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4
RT complex.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:12524-12529(2017).
CC -!- FUNCTION: Transcription regulator complex subunit that is essential for
CC cell cycle progression. {ECO:0000269|PubMed:15388803,
CC ECO:0000269|PubMed:29109278}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15388803}.
CC -!- DISRUPTION PHENOTYPE: Leads to only a few rounds of cell division
CC before arresting with an elongated cell (cdc) phenotype.
CC {ECO:0000269|PubMed:15388803}.
CC -!- SIMILARITY: Belongs to the NC2 alpha/DRAP1 family. {ECO:0000305}.
CC -!- CAUTION: SPAC17G8.03c was previously identified as the homolog of
CC budding yeast DBP3 in fission yeast (PubMed:15388803). However, it was
CC further demonstrated that SPCC16C4.22 is the true ortholog of DBP3
CC (PubMed:29109278). {ECO:0000269|PubMed:15388803,
CC ECO:0000269|PubMed:29109278}.
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DR EMBL; CU329670; CAA93686.1; -; Genomic_DNA.
DR EMBL; AB028008; BAA87312.1; -; Genomic_DNA.
DR PIR; T37855; T37855.
DR RefSeq; NP_593726.1; NM_001019157.2.
DR AlphaFoldDB; Q10315; -.
DR SMR; Q10315; -.
DR BioGRID; 278676; 4.
DR ComplexPortal; CPX-2111; DNA polymerase epsilon complex.
DR IntAct; Q10315; 2.
DR STRING; 4896.SPAC17G8.03c.1; -.
DR iPTMnet; Q10315; -.
DR MaxQB; Q10315; -.
DR PaxDb; Q10315; -.
DR PRIDE; Q10315; -.
DR EnsemblFungi; SPAC17G8.03c.1; SPAC17G8.03c.1:pep; SPAC17G8.03c.
DR GeneID; 2542201; -.
DR KEGG; spo:SPAC17G8.03c; -.
DR PomBase; SPAC17G8.03c; bur6.
DR VEuPathDB; FungiDB:SPAC17G8.03c; -.
DR eggNOG; KOG1659; Eukaryota.
DR HOGENOM; CLU_045277_3_1_1; -.
DR InParanoid; Q10315; -.
DR OMA; ALDGWPK; -.
DR PhylomeDB; Q10315; -.
DR PRO; PR:Q10315; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000785; C:chromatin; NAS:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0008622; C:epsilon DNA polymerase complex; IC:ComplexPortal.
DR GO; GO:0017054; C:negative cofactor 2 complex; ISO:PomBase.
DR GO; GO:0043596; C:nuclear replication fork; NAS:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0001046; F:core promoter sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0006261; P:DNA-templated DNA replication; IC:ComplexPortal.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IC:PomBase.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR027116; Bur6/Dpb3.
DR InterPro; IPR003958; CBFA_NFYB_domain.
DR InterPro; IPR009072; Histone-fold.
DR PANTHER; PTHR10252:SF5; PTHR10252:SF5; 1.
DR Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..199
FT /note="Transcription regulator complex subunit bur6"
FT /id="PRO_0000208348"
FT REGION 106..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 199 AA; 22236 MW; 96233C2DE4AFFBD8 CRC64;
MGDPTNNNDS ETKPNPATYW KSRFPVARIK KIMQADQDVG KVAQVTPVIM SKALELFMQS
IIQESCKQTR LHQAKRVTVS HLKHAVQSVE QFDFLQDIVE KVPDAPPIKA ERKTKRPRAR
RAANEGEHNE SVPAKKVKKN TVKEEEIEKD DESATTETPV KEEPTGEETE ADHEEKASVD
HGNFSDKTTS EASSASGDE
