ID   TRMBR_HALSA             Reviewed;         352 AA.
AC   Q9HPW0;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   14-MAY-2014, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=HTH-type sugar sensing transcriptional regulator TrmB;
GN   Name=trmB; OrderedLocusNames=VNG_1451C;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [2]
RP   FUNCTION, DNA-BINDING, ACTIVITY REGULATION, DISRUPTION PHENOTYPE, AND GENE
RP   NAME.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=19536205; DOI=10.1038/msb.2009.40;
RA   Schmid A.K., Reiss D.J., Pan M., Koide T., Baliga N.S.;
RT   "A single transcription factor regulates evolutionarily diverse but
RT   functionally linked metabolic pathways in response to nutrient
RT   availability.";
RL   Mol. Syst. Biol. 5:282-282(2009).
CC   -!- FUNCTION: Coordinates the expression of genes functioning in central
CC       metabolism and its associated pathways. Acts as both a transcriptional
CC       activator and a repressor in response to carbon source availability.
CC       Binds to an inverted palindromic sequence in the promoters or ORFs of
CC       target genes. {ECO:0000269|PubMed:19536205}.
CC   -!- ACTIVITY REGULATION: Does not bind DNA in the presence of high glucose
CC       or glycerol. {ECO:0000269|PubMed:19536205}.
CC   -!- DOMAIN: Contains an N-terminal DNA-binding domain and a C-terminal
CC       sugar-binding domain. {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Deletion causes severe growth defect in various
CC       conditions, such as nutrient starvation in defined media, metal
CC       depletion and excess, and oxidative stress.
CC       {ECO:0000269|PubMed:19536205}.
CC   -!- SIMILARITY: Belongs to the transcriptional regulator TrmB family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG19757.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE004437; AAG19757.1; ALT_INIT; Genomic_DNA.
DR   PIR; A84299; A84299.
DR   RefSeq; WP_049892507.1; NC_002607.1.
DR   AlphaFoldDB; Q9HPW0; -.
DR   SMR; Q9HPW0; -.
DR   STRING; 64091.VNG_1451C; -.
DR   PaxDb; Q9HPW0; -.
DR   EnsemblBacteria; AAG19757; AAG19757; VNG_1451C.
DR   GeneID; 5952980; -.
DR   KEGG; hal:VNG_1451C; -.
DR   PATRIC; fig|64091.14.peg.1107; -.
DR   HOGENOM; CLU_062979_2_0_2; -.
DR   InParanoid; Q9HPW0; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR021586; Tscrpt_reg_TrmB_C.
DR   InterPro; IPR002831; Tscrpt_reg_TrmB_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF11495; Regulator_TrmB; 1.
DR   Pfam; PF01978; TrmB; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..352
FT                   /note="HTH-type sugar sensing transcriptional regulator
FT                   TrmB"
FT                   /id="PRO_0000428838"
FT   DNA_BIND        36..57
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   352 AA;  38361 MW;  076CB2D54240A213 CRC64;
     MSDEDLRGTV EQVGRGFNLG EYEVEAYLTV LRHGELTASD IADRTDIPQP RVYDTVRSLG
     DRGLVELRES RPMKIVALSP EDAFAGLQED FQEMVGALEA EYTQPARNTE AVSLVKSRST
     IVRYFGDVIA EADFELVCSL TPSLLERFAD DLAAAVDRGV SVDVVVSPAR NAPNPDAFDY
     AAATTAARGR RGITTPVIAV ADGRYSVYAT QDAVRDDSDR YGVIFDQSAL GFLVSGFFDT
     VLWSTATESL YDPATELSLP RTYAAIRRCV RDLQSVDESV YATVTGRDVL TGADRRIQGR
     IVETRFEESG EVATIIVYTE NGDRVEVGGR VAALEDVEAH EIAVARDAPP AL