BURS_AEDAE
ID BURS_AEDAE Reviewed; 163 AA.
AC P85316;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 25-MAY-2022, entry version 33.
DE RecName: Full=Bursicon;
DE AltName: Full=Bursicon subunit alpha;
DE Flags: Precursor;
GN Name=burs124 {ECO:0000250|UniProtKB:Q66Q82};
GN and
GN Name=burs3 {ECO:0000250|UniProtKB:Q66Q82};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000305}
RP CONCEPTUAL TRANSLATION, AND TRANS-SPLICING.
RX PubMed=17435221; DOI=10.1534/genetics.107.070938;
RA Robertson H.M., Navik J.A., Walden K.K.O., Honegger H.-W.;
RT "The bursicon gene in mosquitoes: an unusual example of mRNA trans-
RT splicing.";
RL Genetics 176:1351-1353(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Final heterodimeric neurohormone released at the end of the
CC molting cycle, involved in the sclerotization (tanning) of the insect
CC cuticle, melanization and wing spreading.
CC {ECO:0000250|UniProtKB:Q9VD83}.
CC -!- SUBUNIT: Heterodimer of burs and pburs. {ECO:0000250|UniProtKB:Q9VD83}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9VD83}.
CC -!- MISCELLANEOUS: The bursicon gene is encoded by two loci: burs124
CC contains exons 1, 2 and 4, and burs3 contains exon 3. Exon 3 is trans-
CC spliced into position in the mature transcript. This unusual gene
CC arrangement has existed for at least the 150 million years (MY) of
CC mosquito evolution since the split of the culicid and anophelid family
CC lineages, but is younger than the 250 MY split of the dipteran
CC suborders Nematocera and Brachycera (containing the Culicidea and
CC Drosophilidae, respectively). {ECO:0000269|PubMed:17435221}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH477322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH477412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P85316; -.
DR VEuPathDB; VectorBase:AAEL026321; -.
DR InParanoid; P85316; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR GO; GO:0007593; P:chitin-based cuticle sclerotization; ISS:UniProtKB.
DR GO; GO:0048067; P:cuticle pigmentation; ISS:UniProtKB.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR Pfam; PF03045; DAN; 1.
DR SMART; SM00041; CT; 1.
DR PROSITE; PS01225; CTCK_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..163
FT /note="Bursicon"
FT /evidence="ECO:0000255"
FT /id="PRO_0000312827"
FT DOMAIN 39..129
FT /note="CTCK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 39..88
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 53..102
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 63..123
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 67..125
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 85..128
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT DISULFID 87
FT /note="Interchain"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 163 AA; 17719 MW; 57AF670D39AF35B4 CRC64;
MKSSVCVLLK VLACILLPGG LNAQKESNDD IQHYTADDCQ VTPVIHVLQY PGCVPKPIPS
FACIGRCASY IQVSGSKIWQ MERSCMCCQE SGEREASVSL FCPKAKNGEK KFKKVSTKAP
LECMCRPCTG IEDANVIPQE LAAFADDGSL AGYFQKSQFK AAE
